Colonic Cell Proliferation in Normal Mucosa of Patients with Colon Cancer

Authors

  • Aldo Becciolini From the Laboratory of Radiation Biology, Department of Clinical Physiopathology (A. Becciolini, M. Balzi, P. Faraoni, E. Tisti, G.D. Zappoli Thyrion, V. Giache` ), and Clinica Chirurgica (L. Bandettini), University of Florence, Florence, Italy, and CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK (C. S. Potten)
  • Manuela Balzi From the Laboratory of Radiation Biology, Department of Clinical Physiopathology (A. Becciolini, M. Balzi, P. Faraoni, E. Tisti, G.D. Zappoli Thyrion, V. Giache` ), and Clinica Chirurgica (L. Bandettini), University of Florence, Florence, Italy, and CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK (C. S. Potten)
  • Paola Faraoni From the Laboratory of Radiation Biology, Department of Clinical Physiopathology (A. Becciolini, M. Balzi, P. Faraoni, E. Tisti, G.D. Zappoli Thyrion, V. Giache` ), and Clinica Chirurgica (L. Bandettini), University of Florence, Florence, Italy, and CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK (C. S. Potten)
  • Elena Tisti From the Laboratory of Radiation Biology, Department of Clinical Physiopathology (A. Becciolini, M. Balzi, P. Faraoni, E. Tisti, G.D. Zappoli Thyrion, V. Giache` ), and Clinica Chirurgica (L. Bandettini), University of Florence, Florence, Italy, and CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK (C. S. Potten)
  • Giorgia Zappoli Thyrion From the Laboratory of Radiation Biology, Department of Clinical Physiopathology (A. Becciolini, M. Balzi, P. Faraoni, E. Tisti, G.D. Zappoli Thyrion, V. Giache` ), and Clinica Chirurgica (L. Bandettini), University of Florence, Florence, Italy, and CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK (C. S. Potten)
  • Valentino Giachè From the Laboratory of Radiation Biology, Department of Clinical Physiopathology (A. Becciolini, M. Balzi, P. Faraoni, E. Tisti, G.D. Zappoli Thyrion, V. Giache` ), and Clinica Chirurgica (L. Bandettini), University of Florence, Florence, Italy, and CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK (C. S. Potten)
  • Luca Bandettini From the Laboratory of Radiation Biology, Department of Clinical Physiopathology (A. Becciolini, M. Balzi, P. Faraoni, E. Tisti, G.D. Zappoli Thyrion, V. Giache` ), and Clinica Chirurgica (L. Bandettini), University of Florence, Florence, Italy, and CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK (C. S. Potten)
  • Christopher S. Potten From the Laboratory of Radiation Biology, Department of Clinical Physiopathology (A. Becciolini, M. Balzi, P. Faraoni, E. Tisti, G.D. Zappoli Thyrion, V. Giache` ), and Clinica Chirurgica (L. Bandettini), University of Florence, Florence, Italy, and CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK (C. S. Potten)

DOI:

https://doi.org/10.1080/028418698423195

Abstract

Cell kinetics parameters have been analysed in colonic mucosa at different distances from a tumour in patients with colon carcinoma. Total cell number (TCN), H thymidine labelling index (TLI), mitotic index (MI), Goblet cell index (GCI) and the distribution of labelled cells along the crypt column (cell position frequency plot) were determined in well-aligned crypts. Total cell number, GCI and the labelled cell position frequency plots were similar in different samples from the same individual. A negative linear correlation between TCN and TLI was observed. The analysis of the cell position plots showed two patterns 1) with a high concentration in the bottom fifth of the crypt and 2) with frequent labelled cells at high positions. Whereas a negative correlation between overall TLI and the percent contribution to the TLI of the lowermost fifth was seen, the correlation was positive for the next 3 fifths and labelling was absent in the last part of the crypt.

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Published

1998-01-01

How to Cite

Becciolini, A. ., Balzi, M. ., Faraoni, P. ., Tisti, E. ., Thyrion, G. Z. ., Giachè, V. ., … Potten, C. S. . (1998). Colonic Cell Proliferation in Normal Mucosa of Patients with Colon Cancer. Acta Oncologica, 37(1), 65–71. https://doi.org/10.1080/028418698423195

Issue

Vol. 37 No. 1 (1998): Acta Oncologica

Section

Articles