Low Detection Rate of HPV in Oral and Laryngeal Carcinomas

Authors

  • Torkjel Matzow From the Departments of Pathology and ENT, The Norwegian National University Hospital, Oslo, Norway, (T. Matzow, B. Hagmar, M. Boysen) and the Department of Clinical Virology, Huddinge University Hospital, Huddinge, Sweden (M. Kalantari, B. Johansson)
  • Morten Boysen From the Departments of Pathology and ENT, The Norwegian National University Hospital, Oslo, Norway, (T. Matzow, B. Hagmar, M. Boysen) and the Department of Clinical Virology, Huddinge University Hospital, Huddinge, Sweden (M. Kalantari, B. Johansson)
  • Mina Kalantari From the Departments of Pathology and ENT, The Norwegian National University Hospital, Oslo, Norway, (T. Matzow, B. Hagmar, M. Boysen) and the Department of Clinical Virology, Huddinge University Hospital, Huddinge, Sweden (M. Kalantari, B. Johansson)
  • Bo Johansson From the Departments of Pathology and ENT, The Norwegian National University Hospital, Oslo, Norway, (T. Matzow, B. Hagmar, M. Boysen) and the Department of Clinical Virology, Huddinge University Hospital, Huddinge, Sweden (M. Kalantari, B. Johansson)
  • Bjørn Hagmar From the Departments of Pathology and ENT, The Norwegian National University Hospital, Oslo, Norway, (T. Matzow, B. Hagmar, M. Boysen) and the Department of Clinical Virology, Huddinge University Hospital, Huddinge, Sweden (M. Kalantari, B. Johansson)

DOI:

https://doi.org/10.1080/028418698423203

Abstract

The presence of human papillomaviruses (HPVs) in 38 oral and 16 laryngeal lesions (verrucous hyperplasia, carcinoma in situ and carcinomas) was investigated using the polymerase chain reaction (PCR) technique. All biopsies were fresh frozen and a set of consensus and type-specific primers was used for PCR detection and HPV typing. In oral biopsies a low proportion of HPV-positive cases was found, despite the sensitive techniques. Only one case out of 38, a carcinoma in situ was positive (2.6%). It is thought that this finding reflects a minimal presence of HPV in the oral lesions, but a transient role of virus in the induction of carcinomas cannot be ruled out. Differences in relation to other studies may be geographical and/or methodological. In laryngeal carcinomas (and dysplasias), 3 out of 16 cases were HPV positive. This frequency (19%) concurs with most other studies.

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Published

1998-01-01

How to Cite

Matzow, T. ., Boysen, M. ., Kalantari, M. ., Johansson, B. ., & Hagmar, B. . (1998). Low Detection Rate of HPV in Oral and Laryngeal Carcinomas. Acta Oncologica, 37(1), 73–76. https://doi.org/10.1080/028418698423203

Issue

Vol. 37 No. 1 (1998): Acta Oncologica

Section

Articles