High-dose Radiation Therapy alone for Inoperable Non-small cell Lung Cancer: Experience with Prolonged Overall Treatment Times

Authors

  • Henning Willers From the Hermann-Holthusen-Institute of Radiotherapy at St. George Hospital, Hamburg, Germany (F. Wu rschmidt, H. Bu nemann, H.-P. Heilmann), and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA (H. Willers)
  • Florian Würschmidt From the Hermann-Holthusen-Institute of Radiotherapy at St. George Hospital, Hamburg, Germany (F. Wu rschmidt, H. Bu nemann, H.-P. Heilmann), and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA (H. Willers)
  • Henry Bünemann From the Hermann-Holthusen-Institute of Radiotherapy at St. George Hospital, Hamburg, Germany (F. Wu rschmidt, H. Bu nemann, H.-P. Heilmann), and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA (H. Willers)
  • Hans-Peter Heilmann From the Hermann-Holthusen-Institute of Radiotherapy at St. George Hospital, Hamburg, Germany (F. Wu rschmidt, H. Bu nemann, H.-P. Heilmann), and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA (H. Willers)

DOI:

https://doi.org/10.1080/028418698423258

Abstract

The purpose of this study as to determine the impact of overall treatment time on long-term survival after high-dose radiation therapy alone for inoperable non-small cell lung cancer (NSCLC). Between 1978 and 1990, 229 patients with stage I-III disease and Karnofsky Performance Scores of 80-100 received a conventionally fractionated total dose of 70 Gy through a split-course technique. After a first treatment course of 40 or 50 Gy, a restaging was performed and only patients without any contraindications, such as newly diagnosed distant metastases or serious deterioration of performance status, were given a second course. In 83% of patients this break lasted for 4-6 weeks. Overall treatment time ranged between 7 and 24 weeks (median 12 weeks). Median follow-up time was 6.6 years (range 4.0-9.3 years). Actuarial overall survival rates at 2 and 5 years were 28% and 7% respectively. 

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Published

1998-01-01

How to Cite

Willers, H. ., Würschmidt, F. ., Bünemann, H. ., & Heilmann, H.-P. . (1998). High-dose Radiation Therapy alone for Inoperable Non-small cell Lung Cancer: Experience with Prolonged Overall Treatment Times. Acta Oncologica, 37(1), 101–105. https://doi.org/10.1080/028418698423258

Issue

Vol. 37 No. 1 (1998): Acta Oncologica

Section

Articles