Expression of Fibroblast Growth Factor 2 mRNA in Early and Advanced Gastric Cancer

Authors

  • Masao Noda Department of Pathology, Shiga University of Medical Science, Shiga; Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Histopathology, Royal Postgraduate Medical School, London, UK
  • Takanori Hattori Department of Pathology, Shiga University of Medical Science, Shiga
  • Tsuguhiro Kimura Department of Pathology, Shiga University of Medical Science, Shiga; Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Hiroyuki Naitoh Department of Pathology, Shiga University of Medical Science, Shiga
  • Tadashi Kodama Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Kei Kashima Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Massimo Pignatelli Department of Histopathology, Royal Postgraduate Medical School, London, UK

DOI:

https://doi.org/10.3109/02841869709001339

Abstract

We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridisation to elucidate its role in cancer progression. Anti-sense RNA probes were synthesized by transcribing the subcloned vector with T7 RNA polymerase in the presence of digoxigenin-labeled UTP. FGF-2 mRNA was located mainly in the cytoplasm around the nuclei of endothelial cells, fibroblasts and carcinoma cells. The expression was more frequently in the diffuse type carcinomas (4/7, 57%) than in the intestinal type tumours (5/23, 22%). The survival rates of advanced gastric cancers with FGF-2 mRNA expression were significantly lower than those without FGF-2 mRNA expression (p < 0.01). No significant correlation was seen with other clinicopathological factors. These results suggest that FGF-2 may play an important role for the growth of diffuse type gastric cancers, particularly at their advanced stage.

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Published

1997-01-01

How to Cite

Noda, M., Hattori, T. ., Kimura, T. ., Naitoh, H. ., Kodama, T. ., Kashima, K. ., & Pignatelli, M. . (1997). Expression of Fibroblast Growth Factor 2 mRNA in Early and Advanced Gastric Cancer. Acta Oncologica, 36(7), 695–700. https://doi.org/10.3109/02841869709001339

Issue

Vol. 36 No. 7 (1997): Acta Oncologica

Section

Articles