Antiemetic Effects of Lerisetron in Radiation-induced Emesis in the Dog

Authors

  • Ignacio A. Gomez-de-Segura From the Departments of Experimental Surgery (I.A. Gomez-de-Segura, E. De Miguel) and Oncology Radiotherapy (A.G. Grande), La Paz Hospital, Madrid, Spain
  • Antonio G. Grande From the Departments of Experimental Surgery (I.A. Gomez-de-Segura, E. De Miguel) and Oncology Radiotherapy (A.G. Grande), La Paz Hospital, Madrid, Spain
  • Enrique De Miguel From the Departments of Experimental Surgery (I.A. Gomez-de-Segura, E. De Miguel) and Oncology Radiotherapy (A.G. Grande), La Paz Hospital, Madrid, Spain

DOI:

https://doi.org/10.1080/028418698430160

Abstract

The 5-HT3 receptor antagonists are the most potent antiemetics known at present. Lerisetron is a new 5-HT3 receptor antagonist chemically unrelated to other antagonists like Ondansetron. An emesis model in the dog induced by irradiation with 60Co was used, and 8 Gy were administered over the total body surface. An irradiated control group was established and received no medication, and two irradiated groups received treatment with either Ondansetron or Lerisetron. The 'up-down' technique was employed to determine the effective dose (ED50

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Published

1998-01-01

How to Cite

Gomez-de-Segura, I. A. ., Grande, A. G. ., & De Miguel, E. . (1998). Antiemetic Effects of Lerisetron in Radiation-induced Emesis in the Dog. Acta Oncologica, 37(7-8), 759–763. https://doi.org/10.1080/028418698430160

Issue

Vol. 37 No. 7-8 (1998): Acta Oncologica

Section

Articles