Cell Kinetics of Head and Neck Squamous Cell Carcinomas: Prognostic implications

Authors

  • Karin Nylander Department of Oral Pathology, University of Umeå, Sweden
  • Göran Anneroth Department of Oral Pathology, University of Umeå, Sweden
  • Hans Gustafsson Department of Otorhinolaryngology, University of Umeå, Sweden
  • Göran Roos Department of Pathology, University of Umeå, Sweden
  • Roger Stenling Department of Pathology, University of Umeå, Sweden
  • Björn Zackrisson Department of Oncology, University of Umeå, Sweden

DOI:

https://doi.org/10.3109/02841869409098370

Abstract

Forty-three squamous cell carcinomas of the head and neck region were in vivo labelled with the thymidine analogue iododeoxyuridine. Combined flow cytometric (FCM) and immunohistochemical (IHC) analysis was performed, and the following parameters calculated: labelling index (LI), S-phase time (Ts) and potential tumor doubling time (Tpot). Complete FCM and IHC analyses could successfully be performed in 31 cases, showing a median LI of 13.6% with FCM and 9.1% with IHC. A correlation achieved between LI/FCM and LI/IHC was due to the aneuploid cases, whereas the diploid cases showed no such correlation. Data indicated that Tpot calculated with LI from IHC (Tpot/IHC) might be a prognostic factor, in contrast to Tpot determined using LI/FCM.

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Published

1994-01-01

How to Cite

Nylander, K., Anneroth, G., Gustafsson, H., Roos, G., Stenling, R., & Zackrisson, B. (1994). Cell Kinetics of Head and Neck Squamous Cell Carcinomas: Prognostic implications. Acta Oncologica, 33(1), 23–28. https://doi.org/10.3109/02841869409098370

Issue

Vol. 33 No. 1 (1994): Acta Oncologica

Section

Articles