Changes of Blood Viscosity in Patients Treated with 5-Fluorouracil—A Link to Cardiotoxicity?

Authors

  • Magdalena Cwikiel Department of Oncolog, University Hospital, Lund, Sweden
  • Sylvi U. Persson Department of Internal Medicine, University Hospital, Lund, Sweden
  • Hans Larsson Department of Internal Medicine, University Hospital, Lund, Sweden
  • Maria Albertsson Department of Oncolog, University Hospital, Lund, Sweden
  • Jan Eskilsson Department of Cardiology, University Hospital, Lund, Sweden

DOI:

https://doi.org/10.3109/02841869509093643

Abstract

Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU. The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients.

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Published

1995-01-01

How to Cite

Cwikiel, M., Persson, S. U., Larsson, H., Albertsson, M., & Eskilsson, J. (1995). Changes of Blood Viscosity in Patients Treated with 5-Fluorouracil—A Link to Cardiotoxicity?. Acta Oncologica, 34(1), 83–85. https://doi.org/10.3109/02841869509093643

Issue

Vol. 34 No. 1 (1995): Acta Oncologica

Section

Articles