Pituitary-Gonadal Dysfunction in Male Patients with Lung Cancer: Association with serum inhibin levels

Authors

  • Ulf Aasebø Department of Chest Medicine, University Hospital of Tromsø, Nor-way
  • Roy M. Bremnes Department of Oncology, University Hospital of Tromsø, Nor-way
  • Frank H. De Jong Department of Biochemistry, Erasmus University, Rotterdam, The Netherlands
  • Asbjørn Aakvaag Hormone Laboratory, Haukeland Hospital, Bergen
  • Lars Slørdal Department of Clinical Pharmacology, The Norwegian Radium Hospital, Oslo, Norway

DOI:

https://doi.org/10.3109/02841869409098401

Abstract

Male lung cancer patients with poor performance status have an endocrinological dysfunction shown by decreased serum levels of total and free testosterone (AFTC). The intention was to investigate whether or not inhibin plays a role in gonadal dysfunction observed in male patients with malignant pulmonary disease. Twenty-seven patients with locally advanced non-small cell lung cancer were included. Sixteen patients were within ECOG index 1–2 (group A) and 11 patients within ECOG index 3–4 (group B). Gonadal function was monitored by serum LH, FSH, testosterone, SHBG and inhibin levels. Patients with poor performance status displayed significantly lower inhibin (1.6 ± 0.8 U/l) and AFTC (0.23 ± 0.07 nmol/1) levels when compared to patients within ECOG index 1–2 (inhibin 2.4 4pM 1.1 U/l; AFTC 0.66 ± 0.36 nmol/1). Serum inhibin tended to correlate inversely to FSH with a 4.4-fold higher FSH/inhibin ratio in group B compared to A.

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Published

1994-01-01

How to Cite

Aasebø, U., Bremnes, R. M., De Jong, F. H., Aakvaag, A., & Slørdal, L. (1994). Pituitary-Gonadal Dysfunction in Male Patients with Lung Cancer: Association with serum inhibin levels. Acta Oncologica, 33(2), 177–180. https://doi.org/10.3109/02841869409098401

Issue

Vol. 33 No. 2 (1994): Acta Oncologica

Section

Articles