Optimization of the Dose Level for a Given Treatment Plan to Maximize the Complication-free Tumor Cure

Abstract

During the past decade, tumor and normal tissue reactions after radiotherapy have been increasingly quantified in radiobiological terms. For this purpose, response models describing the dependence of tumor and normal tissue reactions on the irradiated volume, heterogeneity of the delivered dose distribution and cell sensitivity variations can be taken into account. The probability of achieving a good treatment outcome can be increased by using an objective function such as P₊, the probability of complication-free tumor control. A new procedure is presented, which quantifies P₊ from the dose delivery on 2D surfaces and 3D volumes and helps the user