Prognostic Value of Serum Tetranectin in Patients with Metastatic Breast Cancer

Authors

  • Claus K. Høgdall Department of Clinical Biochemistry, Statens Serum-institut, Copenhagen, Denmark
  • György Sölétormos Dept. of Clinical Chemistry Herlev Hospital, University of Copenhagen; Dept. of Oncology, Herlev Hospital, University of Copenhagen
  • Dorte Nielsen Dept. of Oncology, Herlev Hospital, University of Copenhagen
  • Bent Nørgaard-Pedersen Department of Clinical Biochemistry, Statens Serum-institut, Copenhagen, Denmark
  • Per Dombernowsky Dept. of Oncology, Herlev Hospital, University of Copenhagen
  • Inge Clemmensen Dept. of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Denmark

DOI:

https://doi.org/10.3109/02841869309092443

Abstract

To evaluate serum tetranectin as a prognostic marker before first-line chemotherapy, serum levels were studied in 67 patients with metastatic breast cancer. in the Cox analyses, the relative risk (RR) for death of cancer varied with the cut-off level of serum tetranectin. A maximal RR of 5.0 was found for patients with serum tetranectin ≤ 5.4 mg/1. the maximal RR of death for the other prognostic variables were multiple metastases 2.8, and for a poor performance status 2.0. Testing for the outcome, progressive disease, a maximal RR of 3.8 was found for patients with serum tetranectin ≤ 5.3 mg/1, a maximal RR of 3.7 for multiple metastases and a maximal RR of 1.8 for a poor performance status. Significantly lower serum tetranectin values were found in patients with a poor treatment response compared to well responding patients. Serum tetranectrin seems to be useful as an additional prognostic factor in metastatic breast cancer.

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Published

1993-01-01

How to Cite

Høgdall, C. K. ., Sölétormos, G. ., Nielsen, D. ., Nørgaard-Pedersen, B. ., Dombernowsky, P. ., & Clemmensen, I. . (1993). Prognostic Value of Serum Tetranectin in Patients with Metastatic Breast Cancer. Acta Oncologica, 32(6), 631–636. https://doi.org/10.3109/02841869309092443

Issue

Vol. 32 No. 6 (1993): Acta Oncologica

Section

Articles