Prognostic Factors in Malignant Gliomas with Special Reference to Intra-Arterial Chemotherapy

Authors

  • Kjell Watne Department of Neurosurgery, The National Hospital, Oslo, Norway
  • Einar Hannisdal Department of Oncology, The Norwegian Radium Hospital, Oslo, Norway
  • Ole Nome Department of Oncology, The Norwegian Radium Hospital, Oslo, Norway
  • Bjarne Hager Department of Radiology, The Norwegian Radium Hospital, Oslo, Norway
  • Henry Hirschberg Department of Neurosurgery, The National Hospital, Oslo, Norway

DOI:

https://doi.org/10.3109/02841869309093600

Abstract

Survival was analyzed in 173 patients with malignant gliomas to study the importance of possible pretreatment prognostic factors. Seventy-nine of these patients received preirradiation intra-arterial chemotherapy with BCNU combined with vincristine intravenously and procarbazine orally; the others received only postoperative whole-brain irradiation. To judge by univariate and multivariate analyses the most important pretreatment prognostic factors were histology, corticosteroid dependency, pretreatment performance status and frontal lobe location of the tumors. Patients with anaplastic astrocytoma, not corticosteroid-dependent, with pretreatment performance status of 0–2 and with a frontal lobe location of the tumor seemed to benefit most from preirradiation chemotherapy.

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Published

1993-01-01

How to Cite

Watne, K. ., Hannisdal, E. ., Nome, O. ., Hager, B. ., & Hirschberg, H. . (1993). Prognostic Factors in Malignant Gliomas with Special Reference to Intra-Arterial Chemotherapy. Acta Oncologica, 32(3), 307–310. https://doi.org/10.3109/02841869309093600

Issue

Vol. 32 No. 3 (1993): Acta Oncologica

Section

Articles

License

Copyright (c) 1993 Acta Oncologica Foundation

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.