Bleomycin, Methotrexate and Vincristine Before Irradiation of Stage III and IV Laryngeal and Pharyngeal Squamous Cell Carcinoma: A Study Initiated by the Danish Society of Head and Neck Cancer Dahanca I

Authors

  • H. S. Hansen Radium Centre of Copenhagen, Finsen Institute, The Radium Centre Of Aarhus, Municipal Hospital, The Radium Centre Of Odense, Odense Hospital, and Herlev Hospital, University Of Copenhagen, Denmark
  • J. Rygård Radium Centre of Copenhagen, Finsen Institute, The Radium Centre Of Aarhus, Municipal Hospital, The Radium Centre Of Odense, Odense Hospital, and Herlev Hospital, University Of Copenhagen, Denmark
  • A. P. Andersen Radium Centre of Copenhagen, Finsen Institute, The Radium Centre Of Aarhus, Municipal Hospital, The Radium Centre Of Odense, Odense Hospital, and Herlev Hospital, University Of Copenhagen, Denmark
  • J. Munck-Hansen Radium Centre of Copenhagen, Finsen Institute, The Radium Centre Of Aarhus, Municipal Hospital, The Radium Centre Of Odense, Odense Hospital, and Herlev Hospital, University Of Copenhagen, Denmark
  • K. Jørgensen Radium Centre of Copenhagen, Finsen Institute, The Radium Centre Of Aarhus, Municipal Hospital, The Radium Centre Of Odense, Odense Hospital, and Herlev Hospital, University Of Copenhagen, Denmark
  • J. Overgaard Radium Centre of Copenhagen, Finsen Institute, The Radium Centre Of Aarhus, Municipal Hospital, The Radium Centre Of Odense, Odense Hospital, and Herlev Hospital, University Of Copenhagen, Denmark
  • E. Sandberg Radium Centre of Copenhagen, Finsen Institute, The Radium Centre Of Aarhus, Municipal Hospital, The Radium Centre Of Odense, Odense Hospital, and Herlev Hospital, University Of Copenhagen, Denmark
  • M. Hjelm Hansen Radium Centre of Copenhagen, Finsen Institute, The Radium Centre Of Aarhus, Municipal Hospital, The Radium Centre Of Odense, Odense Hospital, and Herlev Hospital, University Of Copenhagen, Denmark

DOI:

https://doi.org/10.3109/02841868709092970

Keywords:

Therapeutic radiology, laryngeal and pharyngeal cancer, preoperative chemotherapy

Abstract

Primary treatment with bleomycin, methotrexate and vincristine for two weeks followed by curatively intended 60Co irradiation was administered to 153 patients consecutively referred to the three main treatment centres in Denmark over more than a two-year period. Seventy-one laryngeal and 82 pharyngeal squamous cell carcinomas were evaluated. According to the TNM classification (UICC) 76 patients had stage III and 77 patients stage IV disease. The immediate response (complete + partial) to chemotherapy was 20 per cent. Judging from frequency of local recurrence, metastases as well as survival the treatment results were not obviously improved. A high frequency of complications was observed after this combination of chemotherapy and irradiation, and it was often impossible to fulfil the irradiation to the planned dose in appropriate time.

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Published

1987-01-01

How to Cite

Hansen, H. S., Rygård, J., Andersen, A. P., Munck-Hansen, J., Jørgensen, K., Overgaard, J., … Hjelm Hansen, M. (1987). Bleomycin, Methotrexate and Vincristine Before Irradiation of Stage III and IV Laryngeal and Pharyngeal Squamous Cell Carcinoma: A Study Initiated by the Danish Society of Head and Neck Cancer Dahanca I. Acta Oncologica, 26(1), 13–18. https://doi.org/10.3109/02841868709092970

Issue

Vol. 26 No. 1 (1987): Acta Oncologica

Section

Articles