Effects of Glucan on the Reticuloendothelial System and on the Development of Tumors in 90Sr-Exposed Mice

Authors

  • Gunnar Walinder The Unit of Experimental Pathology and Risk Research, Swedish University of Agricultural Sciences, Uppsala, Sweden
  • Ram G. Arora The Unit of Experimental Pathology and Risk Research, Swedish University of Agricultural Sciences, Uppsala, Sweden
  • Par Bierke The Unit of Experimental Pathology and Risk Research, Swedish University of Agricultural Sciences, Uppsala, Sweden
  • Agneta Broomé-Karlsson The Unit of Experimental Pathology and Risk Research, Swedish University of Agricultural Sciences, Uppsala, Sweden
  • Britt-Marie Svedenstal The Unit of Experimental Pathology and Risk Research, Swedish University of Agricultural Sciences, Uppsala, Sweden

DOI:

https://doi.org/10.3109/02841869209088290

Abstract

A series of experiments was conducted to examine the effect of glucan on the reticuloendothelial system (RES) and on the development of 90Sr-induced osteosarcomas and malignant lymphomas in CBA/S mice. Glucan demonstrated a strong RES-stimulating effect, as evidenced by a dose-related increase in lysozyme levels in the plasma and an enlargement of the liver and spleen. Weekly injections of glucan between 150 and 250 days after exposure to 90Sr suppressed the actuarial appearance of the fibroblastic type of osteosarcomas and stimulated the emergence of malignant lymphomas. Glucan itself had no tumorigenic effect in mice not exposed to 90Sr.

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Published

1993-01-01

How to Cite

Walinder, G., Arora, R. G., Bierke, P., Broomé-Karlsson, A., & Svedenstal, B.-M. (1993). Effects of Glucan on the Reticuloendothelial System and on the Development of Tumors in 90Sr-Exposed Mice. Acta Oncologica, 31(4), 461–467. https://doi.org/10.3109/02841869209088290

Issue

Vol. 31 No. 4 (1992): Acta Oncologica

Section

Articles