Biokinetics of the Monoclonal Antibodies MOv 18, OV 185 and OV 197 Labelled with 125I According to the m-MeATE Method or the Iodogen Method in Nude Mice with Ovarian Cancer Xenografts

Authors

  • Håkan Andersson Departments of Gynecological Oncology (H. Andersson, G. Leser, G. Horvath), and Radiation Physics (S. Lindegren, T. Ba ck, L. Jacobsson), Sahlgrenska University Hospital, Gothenburg, Sweden
  • Sture Lindegren Departments of Gynecological Oncology (H. Andersson, G. Leser, G. Horvath), and Radiation Physics (S. Lindegren, T. Ba ck, L. Jacobsson), Sahlgrenska University Hospital, Gothenburg, Sweden
  • Tom Bäck Departments of Gynecological Oncology (H. Andersson, G. Leser, G. Horvath), and Radiation Physics (S. Lindegren, T. Ba ck, L. Jacobsson), Sahlgrenska University Hospital, Gothenburg, Sweden
  • Lars Jacobsson Departments of Gynecological Oncology (H. Andersson, G. Leser, G. Horvath), and Radiation Physics (S. Lindegren, T. Ba ck, L. Jacobsson), Sahlgrenska University Hospital, Gothenburg, Sweden
  • Gunilla Leser Departments of Gynecological Oncology (H. Andersson, G. Leser, G. Horvath), and Radiation Physics (S. Lindegren, T. Ba ck, L. Jacobsson), Sahlgrenska University Hospital, Gothenburg, Sweden
  • György Horvath Departments of Gynecological Oncology (H. Andersson, G. Leser, G. Horvath), and Radiation Physics (S. Lindegren, T. Ba ck, L. Jacobsson), Sahlgrenska University Hospital, Gothenburg, Sweden

DOI:

https://doi.org/10.1080/028418699431393

Abstract

The biodistribution of the radiolabelled monoclonal antibodies MOv18, OV185 and OV197 in nude mice with subcutaneous tumours of the human ovarian cancer cell line OVCAR3 was investigated. The early uptake of MOv18 (1-24 h) and the uptake in relation to tumour size were also studied. The antibodies were labelled with 125I according to the Iodogen method or the m-MeATE method, the latter also being suitable for labelling with 211

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Published

1999-01-01

How to Cite

Andersson, H., Lindegren, S., Bäck, T., Jacobsson, L., Leser, G., & Horvath, G. (1999). Biokinetics of the Monoclonal Antibodies MOv 18, OV 185 and OV 197 Labelled with 125I According to the m-MeATE Method or the Iodogen Method in Nude Mice with Ovarian Cancer Xenografts. Acta Oncologica, 38(3), 323–328. https://doi.org/10.1080/028418699431393

Issue

Vol. 38 No. 3 (1999): Acta Oncologica

Section

Articles