Epstein-Barr Virus Distribution in Hodgkin's Disease in an Unselected Swedish Population

Authors

  • Gunilla Enblad Departments of Oncology Radiology and Clinical Immunology (G. Enblad, B. Glimelius), Pathology and Genetics (C. Sundstrom), Uppsala University, Akademiska sjukhuset, Uppsala, Sweden, and the Laboratory of Immunohistology, Institute of Pathology, Aarhus University, Kommunehospitalet (K. Sandvej, G. Pallesen), Aarhus, Denmark
  • Kristian Sandvej Departments of Oncology Radiology and Clinical Immunology (G. Enblad, B. Glimelius), Pathology and Genetics (C. Sundstrom), Uppsala University, Akademiska sjukhuset, Uppsala, Sweden, and the Laboratory of Immunohistology, Institute of Pathology, Aarhus University, Kommunehospitalet (K. Sandvej, G. Pallesen), Aarhus, Denmark
  • Christer Sundstrom Departments of Oncology Radiology and Clinical Immunology (G. Enblad, B. Glimelius), Pathology and Genetics (C. Sundstrom), Uppsala University, Akademiska sjukhuset, Uppsala, Sweden, and the Laboratory of Immunohistology, Institute of Pathology, Aarhus University, Kommunehospitalet (K. Sandvej, G. Pallesen), Aarhus, Denmark
  • Gorm Pallesen Departments of Oncology Radiology and Clinical Immunology (G. Enblad, B. Glimelius), Pathology and Genetics (C. Sundstrom), Uppsala University, Akademiska sjukhuset, Uppsala, Sweden, and the Laboratory of Immunohistology, Institute of Pathology, Aarhus University, Kommunehospitalet (K. Sandvej, G. Pallesen), Aarhus, Denmark
  • Bengt Glimelius Departments of Oncology Radiology and Clinical Immunology (G. Enblad, B. Glimelius), Pathology and Genetics (C. Sundstrom), Uppsala University, Akademiska sjukhuset, Uppsala, Sweden, and the Laboratory of Immunohistology, Institute of Pathology, Aarhus University, Kommunehospitalet (K. Sandvej, G. Pallesen), Aarhus, Denmark

DOI:

https://doi.org/10.1080/028418699431942

Abstract

All patients with Hodgkin's disease (HD) (n=117) identified in the Uppsala/Örebro region of Sweden between 1985 and 1988 were examined for the presence of Epstein-Barr virus (EBV) in the Hodgkin and Reed-Sternberg (HRS) cells. EBV was detected with LMP-1 immunostaining and in situ hybridization for EBERs. Overall, 32 (27%) tumours were EBV-positive but there were significant differences in EBV-positivity between histopathological subgroups (p=0.03). In MC, 8/21 (38%) were positive, in NS 20/67 (23%), LD 3/3, LP 1/5, and in unclassified 0/1. Patients with EBV-positive tumours were significantly older, mean 52 vs. 42 years (p=0.02), and were likely to have significantly more B-symptoms or advanced stage disease. Patients with EBV-positive tumours tended to have a poorer survival rate (p=0.11). The proportion of EBV-positive tumours, and especially the proportion of EBV-positive MC, was lower than previously reported. This could be explained by selection of patients from previous studies, or by differences in EBV-positivity in different geographical or ethnic populations of HD.

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Published

1999-01-01

How to Cite

Enblad, G., Sandvej, K., Sundstrom, C., Pallesen, G., & Glimelius, B. (1999). Epstein-Barr Virus Distribution in Hodgkin’s Disease in an Unselected Swedish Population. Acta Oncologica, 38(4), 425–429. https://doi.org/10.1080/028418699431942

Issue

Vol. 38 No. 4 (1999): Acta Oncologica

Section

Articles