Electrical Potential Difference Across the Stomach Wall and Gastric Morphology in Anaesthetized Pigs After Intravenous Administration of Cytotoxic Drugs

Authors

  • B. Fabrin Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Physiology/Nuclear Medicine, Hvidovre Hospital, Copenhagen, Denmark; Department of Pathology, Bispebjerg Hospital, Copenhagen, Denmark; Departments of Experimental Surgical Research and Medical Physiology, Panum Institute, Copenhagen, Denmark; Department of Oncology, Rigshospitalet, Copenhagen, Denmark
  • L. Højgaard Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Physiology/Nuclear Medicine, Hvidovre Hospital, Copenhagen, Denmark; Department of Pathology, Bispebjerg Hospital, Copenhagen, Denmark; Departments of Experimental Surgical Research and Medical Physiology, Panum Institute, Copenhagen, Denmark; Department of Oncology, Rigshospitalet, Copenhagen, Denmark
  • A. Johansen Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Physiology/Nuclear Medicine, Hvidovre Hospital, Copenhagen, Denmark; Department of Pathology, Bispebjerg Hospital, Copenhagen, Denmark; Departments of Experimental Surgical Research and Medical Physiology, Panum Institute, Copenhagen, Denmark; Department of Oncology, Rigshospitalet, Copenhagen, Denmark
  • H. P. Olesen Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Physiology/Nuclear Medicine, Hvidovre Hospital, Copenhagen, Denmark; Department of Pathology, Bispebjerg Hospital, Copenhagen, Denmark; Departments of Experimental Surgical Research and Medical Physiology, Panum Institute, Copenhagen, Denmark; Department of Oncology, Rigshospitalet, Copenhagen, Denmark
  • J. Madsen Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Physiology/Nuclear Medicine, Hvidovre Hospital, Copenhagen, Denmark; Department of Pathology, Bispebjerg Hospital, Copenhagen, Denmark; Departments of Experimental Surgical Research and Medical Physiology, Panum Institute, Copenhagen, Denmark; Department of Oncology, Rigshospitalet, Copenhagen, Denmark
  • H. T. Mouridsen Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Physiology/Nuclear Medicine, Hvidovre Hospital, Copenhagen, Denmark; Department of Pathology, Bispebjerg Hospital, Copenhagen, Denmark; Departments of Experimental Surgical Research and Medical Physiology, Panum Institute, Copenhagen, Denmark; Department of Oncology, Rigshospitalet, Copenhagen, Denmark

DOI:

https://doi.org/10.3109/02841869109091824

Keywords:

Cancer chemotherapy, side-effects, gastric, transmucosal potential difference, intragastric pH, pig

Abstract

Nausea and vomiting are frequent side-effects of cancer chemotherapy. To investigate whether such therapy has an acute toxic effect on the gastric mucosa, cyclophosphamide, epirubicin and fluorouracil were administered intravenously to anaesthetized pigs. Gastric mucosal function was evaluated by continuous measurements of the gastric transmucosal electrical potential difference (PD) and the intragastric pH by using a newly developed microelectrode principle. After sacrifice, gastric histology was examined. During chemotherapy a significant decline in gastric PD was observed two hours after drug infusion, indicating a hampered gastric mucosal function. Apart from a slight hyperemia, gastric histology was normal. In this animal model a change in gastric mucosal function developed at the same time after chemotherapy as the gastric side-effects in humans.

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Published

1991-01-01

How to Cite

Fabrin, B., Højgaard, L., Johansen, A., Olesen, H. P., Madsen, J., & Mouridsen, H. T. (1991). Electrical Potential Difference Across the Stomach Wall and Gastric Morphology in Anaesthetized Pigs After Intravenous Administration of Cytotoxic Drugs. Acta Oncologica, 30(7), 803–806. https://doi.org/10.3109/02841869109091824

Issue

Vol. 30 No. 7 (1991): Acta Oncologica

Section

Articles