Possible Alteration of the Blood-Brain Barrier by Boron-Neutron Capture Therapy

Authors

  • H. Hatanaka Department of Neurosurgery, Teikyo University, Tokyo, Japan
  • M. Moritani Department of Neurosurgery, Teikyo University, Tokyo, Japan
  • M. Camillo Department of Neurosurgery, Teikyo University, Tokyo, Japan

DOI:

https://doi.org/10.3109/02841869109092389

Keywords:

Neutron capture therapy, mice, brain, blood-brain barrier, fractionated irradiation, boron-10 uptake

Abstract

In the course of re-assessment of boron-neutron capture therapy (BNCT) for malignant brain tumors, fractionation of neutron irradiation has been proposed. the authors have used BNCT with a single fraction technique during the past 21 years and now decided to study some effects of fractionation. Twenty-two healthy mouse brains were irradiated with thermal neutrons after boron-10 injection (mercaptoundecahydrododecaborate). A second dose of boron-10 was administered and its uptake in the boron-neutron-capture-irradiated brains was determined. A tendency towards increased boron uptake in the moderately BNCT-treated brains was noticed, which may result in increased brain damage if fractionated neutron irradiation is used.

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Published

1991-01-01

How to Cite

Hatanaka, H., Moritani, M., & Camillo, M. (1991). Possible Alteration of the Blood-Brain Barrier by Boron-Neutron Capture Therapy. Acta Oncologica, 30(3), 375–378. https://doi.org/10.3109/02841869109092389

Issue

Vol. 30 No. 3 (1991): Acta Oncologica

Section

Articles