Predictive Value of Serum Alkaline Dnase Activity Variations in Treatment of Head and Neck Cancer

Authors

  • A. Economidou-Karaoclou TOXICOLOGIC AND CANCEROLOGIC BIOCHEMISTRY UNIT, UCL 7369; THE CANCEROLOGIC UNIT, UCL 5470, MEDICAL FACULTY, UNIVERSITY OF LOUVAIN, BRUSSELS, BELGIUM
  • M. Opsomer TOXICOLOGIC AND CANCEROLOGIC BIOCHEMISTRY UNIT, UCL 7369; THE CANCEROLOGIC UNIT, UCL 5470, MEDICAL FACULTY, UNIVERSITY OF LOUVAIN, BRUSSELS, BELGIUM
  • M. Lans TOXICOLOGIC AND CANCEROLOGIC BIOCHEMISTRY UNIT, UCL 7369; THE CANCEROLOGIC UNIT, UCL 5470, MEDICAL FACULTY, UNIVERSITY OF LOUVAIN, BRUSSELS, BELGIUM
  • H. S. Taper TOXICOLOGIC AND CANCEROLOGIC BIOCHEMISTRY UNIT, UCL 7369; THE CANCEROLOGIC UNIT, UCL 5470, MEDICAL FACULTY, UNIVERSITY OF LOUVAIN, BRUSSELS, BELGIUM
  • C. Deckers TOXICOLOGIC AND CANCEROLOGIC BIOCHEMISTRY UNIT, UCL 7369; THE CANCEROLOGIC UNIT, UCL 5470, MEDICAL FACULTY, UNIVERSITY OF LOUVAIN, BRUSSELS, BELGIUM
  • M. B. Roberfroid TOXICOLOGIC AND CANCEROLOGIC BIOCHEMISTRY UNIT, UCL 7369; THE CANCEROLOGIC UNIT, UCL 5470, MEDICAL FACULTY, UNIVERSITY OF LOUVAIN, BRUSSELS, BELGIUM

DOI:

https://doi.org/10.3109/02841869009126538

Keywords:

Head and neck cancer, tumor marker, DNase 1, treatment response

Abstract

The aim of this study was to evaluate the variation in serum alkaline DNase activity (SADA) as a means of therapeutic monitoring in patients with head and neck cancer. Blood samples from 40 patients were collected before, during, and some weeks up to months after therapy. A decrease in SADA during treatment was usually associated with a primary clinical response, while no decrease indicated non-response to therapy. In patients with complete tumor regression the initial decrease of SADA was usually followed by an increase exceeding the initial level. A similar increase was not observed in patients with tumor progression.

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Published

1990-01-01

How to Cite

Economidou-Karaoclou, A., Opsomer, M., Lans, M., Taper, H. S., Deckers, C., & Roberfroid, M. B. (1990). Predictive Value of Serum Alkaline Dnase Activity Variations in Treatment of Head and Neck Cancer. Acta Oncologica, 29(2), 163–166. https://doi.org/10.3109/02841869009126538

Issue

Vol. 29 No. 2 (1990): Acta Oncologica

Section

Articles