Vincristine, Doxorubicin and Cyclophosphamide with and without Etoposide in Limited Small Cell Lung Cancer

Authors

  • V. Nikkanen Departments of Radiotherapy and Oncology, and Diseases of the Chest, University Central Hospital, Turku; Department of Radiotherapy, University Central Hospital, Tampere; Department of Radiotherapy, Central Hospital of Middle-Finland, Jyväskylä; Departments of Diseases of Chest, Central Hospital of Kanta-Häme, Hämeenlinna and Satalinna Hospital, Satalinna, Finland
  • K. Lhppo Departments of Radiotherapy and Oncology, and Diseases of the Chest, University Central Hospital, Turku; Department of Radiotherapy, University Central Hospital, Tampere; Department of Radiotherapy, Central Hospital of Middle-Finland, Jyväskylä; Departments of Diseases of Chest, Central Hospital of Kanta-Häme, Hämeenlinna and Satalinna Hospital, Satalinna, Finland
  • A. Ojala Departments of Radiotherapy and Oncology, and Diseases of the Chest, University Central Hospital, Turku; Department of Radiotherapy, University Central Hospital, Tampere; Department of Radiotherapy, Central Hospital of Middle-Finland, Jyväskylä; Departments of Diseases of Chest, Central Hospital of Kanta-Häme, Hämeenlinna and Satalinna Hospital, Satalinna, Finland
  • M. Jakobsson Departments of Radiotherapy and Oncology, and Diseases of the Chest, University Central Hospital, Turku; Department of Radiotherapy, University Central Hospital, Tampere; Department of Radiotherapy, Central Hospital of Middle-Finland, Jyväskylä; Departments of Diseases of Chest, Central Hospital of Kanta-Häme, Hämeenlinna and Satalinna Hospital, Satalinna, Finland
  • M. Järvinen Departments of Radiotherapy and Oncology, and Diseases of the Chest, University Central Hospital, Turku; Department of Radiotherapy, University Central Hospital, Tampere; Department of Radiotherapy, Central Hospital of Middle-Finland, Jyväskylä; Departments of Diseases of Chest, Central Hospital of Kanta-Häme, Hämeenlinna and Satalinna Hospital, Satalinna, Finland
  • S. Paloheimo Departments of Radiotherapy and Oncology, and Diseases of the Chest, University Central Hospital, Turku; Department of Radiotherapy, University Central Hospital, Tampere; Department of Radiotherapy, Central Hospital of Middle-Finland, Jyväskylä; Departments of Diseases of Chest, Central Hospital of Kanta-Häme, Hämeenlinna and Satalinna Hospital, Satalinna, Finland
  • E. Nordman Departments of Radiotherapy and Oncology, and Diseases of the Chest, University Central Hospital, Turku; Department of Radiotherapy, University Central Hospital, Tampere; Department of Radiotherapy, Central Hospital of Middle-Finland, Jyväskylä; Departments of Diseases of Chest, Central Hospital of Kanta-Häme, Hämeenlinna and Satalinna Hospital, Satalinna, Finland

DOI:

https://doi.org/10.3109/02841869009090024

Keywords:

Small cell lung cancer, chemotherapy, vincristine, doxorubicin, cyclophosphamide, etoposide

Abstract

A total of 80 patients with limited disease of small cell lung cancer were randomized to receive either vincristine 1 mg/m2 (max. 2mg), doxorubicin 50 mg/m2 and cyclophosphamide 750 mg/m2 (VAC) i.v. on day 1, or the same drugs and etoposide 80 mg/m2 i.v. daily for 3 days (VACE) every 3 weeks for nine courses. Chest irradiation was given in both regimens after the second course. The response rate was 84% for VAC (41% complete responses) and 75% for VACE (46% complete responses). The median survival time was 10 months with VAC regimen, and 14 months with VACE (difference statistically not significant). The median duration of remission was 8 months with VAC and 14 months with VACE (p = 0.03), and the median survival for complete or partial responders was 12 months and 20 months respectively (p = 0.006). Myelosuppression was significantly greater in the VACE group, and there was one treatment related death in the group receiving VACE. In this study the addition of etoposide to VAC improved the duration of response, but did not lead to longer survival of patients with limited disease of small cell lung cancer.

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Published

1990-01-01

How to Cite

Nikkanen, V., Lhppo, K., Ojala, A., Jakobsson, M., Järvinen, M., Paloheimo, S., & Nordman, E. (1990). Vincristine, Doxorubicin and Cyclophosphamide with and without Etoposide in Limited Small Cell Lung Cancer. Acta Oncologica, 29(4), 421–424. https://doi.org/10.3109/02841869009090024

Issue

Vol. 29 No. 4 (1990): Acta Oncologica

Section

Articles