Primary Irradiation, Surgery or Combined Therapy in Squamous Cell Carcinoma of the Larynx: A comparison of treatment results from two centers

Authors

  • H. Vermund Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • M. Boysen Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • J. H. Brandenburg Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • J. Evensen Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • A.-B. Jacobsen Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • O. Kaalhus Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • J. Tausjø Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • E. Thorud Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • A. L. Wiley Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA
  • F. Winther Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

DOI:

https://doi.org/10.3109/02841869009090038

Keywords:

Laryngeal carcinom, treatment results, comparison

Abstract

We compared two groups of patients with squamous cell carcinoma of the larynx. Group 1 consisted of 483 patients treated from 1958 through 1978. Primary surgery was selected in 41%, pre- or postoperative radiation therapy in 16% and primary radiation therapy in 43%. Group 2 consisted of 247 patients treated from 1978 through 1983. Primary surgery was selected in only 1.6%, pre- or postoperative radiation therapy in 23%, and primary radiation therapy, with surgery in reserve for residual or recurrent carcinoma, in 76%. Although the results were comparable for patients with early stage tumors in the two groups, significantly higher local-regional tumor control rates and corrected survival rates were recorded for patients with advanced tumors in group 2. More patients survived with a cancer-free functional larynx, the surgical salvage rates were higher, the complication rates and the death rates lower in group 2 compared to group 1

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Published

1989-01-01

How to Cite

Vermund, H. ., Boysen, M., Brandenburg, J. H. ., Evensen, J. ., Jacobsen, A.-B., Kaalhus, O. ., … Winther, F. . (1989). Primary Irradiation, Surgery or Combined Therapy in Squamous Cell Carcinoma of the Larynx: A comparison of treatment results from two centers. Acta Oncologica, 29(4), 489–503. https://doi.org/10.3109/02841869009090038

Issue

Vol. 29 No. 4 (1990): Acta Oncologica

Section

Articles