Clinical Features of Carcinoid Syndrome and the Use of Somatostatin Analogue in Its Management

Authors

  • A. I. Vinik DEPARTMENT OF INTERNAL MEDICINE, DIVISION OF ENDOCRINOLOGY, AND THE DEPARTMENT OF SURGERY, THE UNIVERSITY OF MICHIGAN MEDICAL CENTER, ANN ARBOR, MI, 48109, USA
  • N. Thompson DEPARTMENT OF INTERNAL MEDICINE, DIVISION OF ENDOCRINOLOGY, AND THE DEPARTMENT OF SURGERY, THE UNIVERSITY OF MICHIGAN MEDICAL CENTER, ANN ARBOR, MI, 48109, USA
  • F. Eckhauser DEPARTMENT OF INTERNAL MEDICINE, DIVISION OF ENDOCRINOLOGY, AND THE DEPARTMENT OF SURGERY, THE UNIVERSITY OF MICHIGAN MEDICAL CENTER, ANN ARBOR, MI, 48109, USA
  • A. R. Moattari DEPARTMENT OF INTERNAL MEDICINE, DIVISION OF ENDOCRINOLOGY, AND THE DEPARTMENT OF SURGERY, THE UNIVERSITY OF MICHIGAN MEDICAL CENTER, ANN ARBOR, MI, 48109, USA

DOI:

https://doi.org/10.3109/02841868909111212

Keywords:

Carcinoid syndrome, clinical features, somatostatin analogue

Abstract

A review is given on the clinical features of carcinoid syndrome including symtomatology, diagnostics, biochemistry and treatment. We have reviewed the literature on current therapy of carcinoid patients with special emphasis on the use of the somatostatin analogue SMS 20-1995. In addition, we present data on the effects of SMS 201-995 on indices of a clinical, biochemical and tumor growth. Diarrhea is abolished or significantly reduced in 75% of patients, flushing improves in 100%, wheezing in 100% with a decrease in airways resistance, and in one patient myopathy has improved. Blood serotonin is notoriously resistant to intervention and urinary 5-HIAA will decrease in 75% of causes but subsequently rebounds in 38%. Tumors, in general, continue to grow, but this may be slowed or in rare cases tumor growth is arrested. In individual instances the tumor may even infarct, leading to spontaneous cure. Tumors secreting PP, ACTH and calcitonin may be particularly resistant to treatment, whereas VIP secreting tumors appear to be sensitive.

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Published

1989-01-01

How to Cite

Vinik, A. I., Thompson, N., Eckhauser, F., & Moattari, A. R. (1989). Clinical Features of Carcinoid Syndrome and the Use of Somatostatin Analogue in Its Management. Acta Oncologica, 28(3), 389–402. https://doi.org/10.3109/02841868909111212

Issue

Vol. 28 No. 3 (1989): Acta Oncologica

Section

Articles