Clinical Comparison of 11C-ACPC (Aminocyclopentane Carboxylic Acid) and 13N-Ammonia as Tumour Tracers

Authors

  • K. De Vis Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • K. Schelstraete Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • J. Deman Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • F. L. Vermeulen Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • J. Sambre Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • P. Goethals Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • D. Van Haver Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • G. Slegers Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • C. Vandecasteele Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium
  • A. De Schryver Department of Radiation Therapy and Nuclear Medicine, University Hospital, the Laboratory of Electronics and Metrology, the Institute of Nuclear Sciences, the Laboratory of Organic Chemistry and the Laboratory for Analytical Chemistry (Faculty of Pharmacy), State University, B-9000, Ghent, Belgium

DOI:

https://doi.org/10.3109/02841868709091749

Keywords:

Radionuclide imaging, tumour markers, positron scanning, ACPC, l3N-ammonia

Abstract

Positron emission tomography is a potential method for exploring the biochemical behaviour of tumours. In 28 patients with known neoplastic lesions a comparison was made between two agents which are known to be accumulated in malignant tumours, viz. 13N-ammonia and 11C-aminocyclopentane carboxylic acid (ACPC). Absolute concentration of both agents in various tumoural tissues and normal organs was calculated. As a rule a parallelism was found between the two tracers as to their accumulation in a given tumour, although the concentration was often higher for ACPC. In normal tissues the ACPC accumulation was either lower or at most equal to NH, levels. As tumour tracer ACPC is superior to NH3 because of its higher absolute accumulation in many neoplastic lesions and its lower uptake in various non-tumorous tissues. ACPC concentration in tumours seems to be largely independent of blood flow.

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Published

1987-01-01

How to Cite

De Vis, K., Schelstraete, K., Deman, J., Vermeulen, F. L., Sambre, J., Goethals, P., … De Schryver, A. (1987). Clinical Comparison of 11C-ACPC (Aminocyclopentane Carboxylic Acid) and 13N-Ammonia as Tumour Tracers. Acta Oncologica, 26(2), 105–111. https://doi.org/10.3109/02841868709091749

Issue

Vol. 26 No. 2 (1987): Acta Oncologica

Section

Articles