Treatment of Lung Cancer with Bronchial Artery Infusion of Cisplatin and Intravenous Sodium Thiosulfate Rescue

Authors

  • N. Uchiyama Department of Radiology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
  • H. Kobayashi Department of Radiology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
  • M. Nakajo Department of Radiology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
  • S. Shinohara epartment of Radiology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

DOI:

https://doi.org/10.3109/02841868809090319

Keywords:

Chemotherapy, intra-arterial, lung cancer, cispla- tin, bronchial artery infusion, sodium thiosulfate rescue

Abstract

Forty-nine patients with primary lung cancer were treated with bronchial artery infusion of cisplatin and intravenous injection of an antidote, sodium thiosulfate. More than 50% reduction of tumor size (PR) was observed in 8 of 9 small cell carcinomas (SCLC) and in 16 of 40 non-small cell carcinomas (NSCLC). In NSCLC patients PR was obtained in 71% (12/17) after repeated infusions (200 mg cisplatin) and in 17% (4/23) after a single infusion (150 mg cisplatin). There was a significant linear relationship between cisplatin dose and tumor reduction in this group. No severe adverse effects were encountered.

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Published

1988-01-01

How to Cite

Uchiyama, N., Kobayashi, H., Nakajo, M. ., & Shinohara, S. . (1988). Treatment of Lung Cancer with Bronchial Artery Infusion of Cisplatin and Intravenous Sodium Thiosulfate Rescue. Acta Oncologica, 27(1), 57–61. https://doi.org/10.3109/02841868809090319

Issue

Vol. 27 No. 1 (1988): Acta Oncologica

Section

Articles