Chromosome Analysis of in Situ Breast Cancer

Authors

  • K. V. Nielsen The Department of Pathology and Surgical Department K, Odense University Hospital, Odense
  • M. Blichert-Toft The Department of Pathology and Surgical Department K, Odense University Hospital, Odense
  • J. Andersen The Section of Clinlcal Genetics, Department of Gynecology and Obstetrics, Rigshospitalet, Copenhagen, Denmark

DOI:

https://doi.org/10.3109/02841868909092332

Keywords:

Breast cancer, carcinoma in situ, chromosomes, genetic heterogeneity, ploidy levels

Abstract

Eleven ductal carcinoma in situ (DCIS), 5 DCIS with microin-vasion and 4 benign lesions have been investigated cytogenetical-ly. Twelve of the 20 breast tumors (60%) had sufficient mitotic activity for chromosome analysis. All ductal carcinoma in situ had abnormal karyotypes, and clonal marker chromosomes could be identified in all tumors analyzed. None were cytogenetically normal. All but one of the 12 DCIS showed genetic heterogeneity. Tumor progression seems to be associated with loss of chromosomes.

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Published

2009-01-01

How to Cite

Nielsen, K. V., Blichert-Toft, M., & Andersen, J. (2009). Chromosome Analysis of in Situ Breast Cancer. Acta Oncologica, 28(6), 919–922. https://doi.org/10.3109/02841868909092332

Issue

Vol. 28 No. 6 (1989): Acta Oncologica

Section

Articles