Tumor Markers in Mammary Carcinoma: An evaluation of carcinoembryonic antigen, placental alkaline phosphatase, pseudouridine and CA-50

Authors

  • T. Rasmuson Department of Onology and Microbiology, The Oncologic Center, Clinical Chemistry and Physiological Chemistry, University of Umeå, S-90187, Umeå; Department of Oncology, Regionsjukhuset, S-70185, Örebro, Sweden
  • G. R. Björk Department of Onology and Microbiology, The Oncologic Center, Clinical Chemistry and Physiological Chemistry, University of Umeå, S-90187, Umeå; Department of Oncology, Regionsjukhuset, S-70185, Örebro, Sweden
  • L. Damber Department of Onology and Microbiology, The Oncologic Center, Clinical Chemistry and Physiological Chemistry, University of Umeå, S-90187, Umeå; Department of Oncology, Regionsjukhuset, S-70185, Örebro, Sweden
  • L. Jacobsson Department of Onology and Microbiology, The Oncologic Center, Clinical Chemistry and Physiological Chemistry, University of Umeå, S-90187, Umeå; Department of Oncology, Regionsjukhuset, S-70185, Örebro, Sweden
  • A. Jeppsson Department of Onology and Microbiology, The Oncologic Center, Clinical Chemistry and Physiological Chemistry, University of Umeå, S-90187, Umeå; Department of Oncology, Regionsjukhuset, S-70185, Örebro, Sweden
  • T. Stigbrand Department of Onology and Microbiology, The Oncologic Center, Clinical Chemistry and Physiological Chemistry, University of Umeå, S-90187, Umeå; Department of Oncology, Regionsjukhuset, S-70185, Örebro, Sweden
  • G. Westman Department of Onology and Microbiology, The Oncologic Center, Clinical Chemistry and Physiological Chemistry, University of Umeå, S-90187, Umeå; Department of Oncology, Regionsjukhuset, S-70185, Örebro, Sweden

DOI:

https://doi.org/10.3109/02841868709089972

Keywords:

Breast neoplasms, carcinoma, CEA, placental alkaline phosphatase, pseudouridine, CA-50, tobacco smoking

Abstract

In 104 patients with breast cancer, carcinoembryonic antigen (Cea), placental alkaline phosphatase (Plap) and the carbohydrate antigen CA-50 were analysed in serum. Excretion of the modified nucleoside, pseudouridine, was analysed in urine. The patients were subdivided in three different clinical stages according to disease manifestations. Levels of Cea and pseudouridine correlated to clinical stage and 58 per cent of the patients with distant metastases had elevated levels of Cea, compared with 36 per cent for pseudouridine. For Plap and CA-50, the levels did not show any clear correlation to clinical stage. Increased activity of Plap correlated strongly to tobacco smoking. A decrease in the level of Cea was observed following radical mastectomy. Increase in Cea levels predicted relapse in 5 out of 14 patients within about 3 to 6 months. In patients with tumor manifestations, elevated Cea levels predicted an inferior prognosis compared to those with ordinary levels.

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Published

1987-01-01

How to Cite

Rasmuson, T., Björk, G. R., Damber, L., Jacobsson, L., Jeppsson, A., Stigbrand, T., & Westman, G. (1987). Tumor Markers in Mammary Carcinoma: An evaluation of carcinoembryonic antigen, placental alkaline phosphatase, pseudouridine and CA-50. Acta Oncologica, 26(4), 261–267. https://doi.org/10.3109/02841868709089972

Issue

Vol. 26 No. 4 (1987): Acta Oncologica

Section

Articles