Prognostic Factors in Locally Advanced Breast Cancer (T3, T4) with Special Reference to Tumor Cell DNA Content

Authors

  • C. Arnerlöv Departments of Surgery, Clinical Cytology, Pathology, and Oncologic Centre, University Hospital, University of Umeå, S-90185, Umeå, Sweden
  • S. O. Emdin Departments of Surgery, Clinical Cytology, Pathology, and Oncologic Centre, University Hospital, University of Umeå, S-90185, Umeå, Sweden
  • G. Roos Departments of Surgery, Clinical Cytology, Pathology, and Oncologic Centre, University Hospital, University of Umeå, S-90185, Umeå, Sweden
  • T. Ångström Departments of Surgery, Clinical Cytology, Pathology, and Oncologic Centre, University Hospital, University of Umeå, S-90185, Umeå, Sweden
  • L. Bjersing Departments of Surgery, Clinical Cytology, Pathology, and Oncologic Centre, University Hospital, University of Umeå, S-90185, Umeå, Sweden
  • K.-A. Ängquist Departments of Surgery, Clinical Cytology, Pathology, and Oncologic Centre, University Hospital, University of Umeå, S-90185, Umeå, Sweden
  • L.-G. Larsson Departments of Surgery, Clinical Cytology, Pathology, and Oncologic Centre, University Hospital, University of Umeå, S-90185, Umeå, Sweden
  • H. Jonsson Departments of Surgery, Clinical Cytology, Pathology, and Oncologic Centre, University Hospital, University of Umeå, S-90185, Umeå, Sweden

DOI:

https://doi.org/10.3109/02841868809093529

Keywords:

Breast, neoplasms; T3 and T4 carcinoma, DNA pattern, prognosis, K.-A. ÄngquistK.-A. ÄngquistK.-A. ÄngquistK.-A. ÄngquistK.-A. Ängquist

Abstract

The prognostic value of DNA analysis was studied retrospectively in 91 patients with locally advanced breast cancer (T3, T4) and a follow-up time of 3–7 years. Tumor cell DNA analysis was performed by static cytometry on aspiration biopsy specimens in 42 cases and on tissue sections in 49 cases. The tumors were classified as euploid or aneuploid. Sixty-four percent of the tumors were aneuploid. DNA pattern correlated significantly to histologic grade and axillary perinodal growth and also to survival. DNA pattern, histologic grade and axillary node metastases correlated significantly to disease-free survival (DFS). In this series of patients with locally advanced breast cancer DNA determinations gave important prognostic information.

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Published

1988-01-01

How to Cite

Arnerlöv, C., Emdin, S. O., Roos, G., Ångström, T., Bjersing, L., Ängquist, K.-A., … Jonsson, H. (1988). Prognostic Factors in Locally Advanced Breast Cancer (T3, T4) with Special Reference to Tumor Cell DNA Content. Acta Oncologica, 27(3), 221–226. https://doi.org/10.3109/02841868809093529

Issue

Vol. 27 No. 3 (1988): Acta Oncologica

Section

Articles