Ability of Lithium to Accelerate the Recovery of Granulopoiesis after Subacute Radiation Injury

Authors

  • V. S. Gallicchio DEPARTMENT OF THERAPEUTIC RADIOLOGY, YALE UNIVERSITY SCHOOL OF MEDICINE, NEW HAVEN, CONNECTICUT, 06510, USA
  • M. G. Chen DEPARTMENT OF THERAPEUTIC RADIOLOGY, YALE UNIVERSITY SCHOOL OF MEDICINE, NEW HAVEN, CONNECTICUT, 06510, USA
  • T. D. Watts DEPARTMENT OF THERAPEUTIC RADIOLOGY, YALE UNIVERSITY SCHOOL OF MEDICINE, NEW HAVEN, CONNECTICUT, 06510, USA

DOI:

https://doi.org/10.3109/02841868409136034

Abstract

Lithium stimulates granulopoietic recovery after mice are exposed to 2 Gy. By examining the hematopoietic inductive microenvironment (HIM) using the stromal colony assay, we demonstrate here that lithium, during the two weeks after irradiation, produced less stromal colony suppression than was observed from the irradiated controls. Recovery peaked by day 19 and returned to normal by day 28. This response was also observed in splenic derived stroma. Furthermore, stroma from lithium-irradiated animals supported the in vitro growth of granulocyte-macrophage colonies (CFU-GM) greater than observed from irradiated controls. These data suggest lithium accelerates granulopoietic recovery by first providing for a completely reconstituted and functional HIM.

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Published

1984-01-01

How to Cite

Gallicchio, V. S. ., Chen, M. G. ., & Watts, T. D. . (1984). Ability of Lithium to Accelerate the Recovery of Granulopoiesis after Subacute Radiation Injury. Acta Oncologica, 23(5), 361–366. https://doi.org/10.3109/02841868409136034

Issue

Vol. 23 No. 5 (1984): Acta Radiologica: Oncology

Section

Articles

License

Copyright (c) 1984 Acta Oncologica

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.