The Effect of Surgery, Radiation Therapy, and Combined Radiation Therapy and Chemotherapy on Immunocompetence in Patients with Lung Carcinoma

Authors

  • M. Jakobsson Departments of Radiation Therapy, Anaesthesiology, and Surgery, Oulu University Central Hospital, the Paivarinne Hospital For Pulmonary Diseases, and the Public Health Laboratory, Oulu, Finland
  • P. I. Taskinen Departments of Radiation Therapy, Anaesthesiology, and Surgery, Oulu University Central Hospital, the Paivarinne Hospital For Pulmonary Diseases, and the Public Health Laboratory, Oulu, Finland
  • P. Ryhänen Departments of Radiation Therapy, Anaesthesiology, and Surgery, Oulu University Central Hospital, the Paivarinne Hospital For Pulmonary Diseases, and the Public Health Laboratory, Oulu, Finland
  • A. Hollmén Departments of Radiation Therapy, Anaesthesiology, and Surgery, Oulu University Central Hospital, the Paivarinne Hospital For Pulmonary Diseases, and the Public Health Laboratory, Oulu, Finland
  • E. Herva Departments of Radiation Therapy, Anaesthesiology, and Surgery, Oulu University Central Hospital, the Paivarinne Hospital For Pulmonary Diseases, and the Public Health Laboratory, Oulu, Finland
  • P. Kärkölä Departments of Radiation Therapy, Anaesthesiology, and Surgery, Oulu University Central Hospital, the Paivarinne Hospital For Pulmonary Diseases, and the Public Health Laboratory, Oulu, Finland
  • M. Saloheimo Departments of Radiation Therapy, Anaesthesiology, and Surgery, Oulu University Central Hospital, the Paivarinne Hospital For Pulmonary Diseases, and the Public Health Laboratory, Oulu, Finland

DOI:

https://doi.org/10.3109/02841868509134420

Abstract

The immunologic status of 59 patients with lung carcinoma was determined by analysis of peripheral venous blood samples. The following tests were performed: total leucocyte and lymphocyte counts, the number of acid alpha-naphthyl acetate esterase (ANAE) positive cells (T-cells), and phytohaemagglutinin (PHA) and tuberculin (PPD) transformation tests. The patients were divided into three treatment groups: a surgery group (S), a radiation therapy group (R), and a combined cytostatic and radiation therapy group (C). A follow-up was carried out 4 to 6 months after treatment. The therapeutic measures, resection, irradiation, and chemotherapy, produced a decrease in the total leucocyte and lymphocyte counts, in the number of T-cells, and in the leucocyte transformation response to PPD. In the surgically treated group the decrease was transient. In the groups treated with radiation therapy and combined cytostatic and radiation therapy the values remained low throughout the follow-up. The lymphocyte response to PHA was not altered in any of the groups during initial treatment. or follow-up. The results did not suggest a correlation between the immunologic parameters used and the stage and histologic type of lung cancer. The tests were of no clinical value in the determination of the individual prognosis.

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Published

1985-01-01

How to Cite

Jakobsson, M., Taskinen, P. I., Ryhänen, P., Hollmén, A., Herva, E., Kärkölä, P., & Saloheimo, M. (1985). The Effect of Surgery, Radiation Therapy, and Combined Radiation Therapy and Chemotherapy on Immunocompetence in Patients with Lung Carcinoma. Acta Oncologica, 24(6), 481–486. https://doi.org/10.3109/02841868509134420

Issue

Vol. 24 No. 6 (1985): Acta Radiologica: Oncology

Section

Articles