Radiosensitizing Effects of Nicotinamide on a C3H Mouse Mammary Adenocarcinoma a Study on Per Os Drug Administration

Authors

  • E. Kjellén Department of Molecular Ecogenetics, Wallenberg Laboratory, University of Lund, s-22185, Lund, Sweden; The Departments of Oncology and Pathology, University Hospital, s-22185, Lund, Sweden
  • R. W. Pero Department of Molecular Ecogenetics, Wallenberg Laboratory, University of Lund, s-22185, Lund, Sweden; The Departments of Oncology and Pathology, University Hospital, s-22185, Lund, Sweden
  • R. Cameron Department of Molecular Ecogenetics, Wallenberg Laboratory, University of Lund, s-22185, Lund, Sweden; The Departments of Oncology and Pathology, University Hospital, s-22185, Lund, Sweden
  • J. Ranstam Department of Molecular Ecogenetics, Wallenberg Laboratory, University of Lund, s-22185, Lund, Sweden; The Departments of Oncology and Pathology, University Hospital, s-22185, Lund, Sweden

DOI:

https://doi.org/10.3109/02841868609136419

Keywords:

Radiation biology, nicotinamide, radiosensitizing effect, mice

Abstract

Nicotinamide is an inhibitor of adenosine diphosphate ribosyl transferase (ADPRT) which is involved in the mechanism of DNA repair after high doses of ionizing radiation. C3H mice with transplanted mammary adenocarcinomas were treated with low doses of nicotinamide, 10 mg/kg, 5 days a week, and in combination with ionizing radiation, 30 Gy, using different drug dose schedules. Mice given nicotinamide in combination with irradiation took a longer time to reach a tumor volume of 1 000 mm3 and a higher complete response rate (i.e. defined as total disappearance of the tumor for at least 7 days) than those given radiation alone. This was true whether nicotinamide was given daily from one week before tumor transplantation until the animal was killed or from transplantation day until day of irradiation. In addition, nicotinamide given per os at a dose between the recommended maximum daily allowance for human subjects (20 mg/70 kg), and the therapeutic allowance (1 g-12 g daily) 5 days a week for 9 weeks, showed a radiosensitizing effect without any histologically detectable damage to the normal tissues of the mouse, including bone marrow, intestine and the liver.

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Published

1986-01-01

How to Cite

Kjellén, E., Pero, R. W., Cameron, R., & Ranstam, J. (1986). Radiosensitizing Effects of Nicotinamide on a C3H Mouse Mammary Adenocarcinoma a Study on Per Os Drug Administration. Acta Oncologica, 25(4-6), 281–284. https://doi.org/10.3109/02841868609136419

Issue

Vol. 25 No. 4-6 (1986): Acta Radiologica: Oncology

Section

Articles