Protective Effect of Selenium Against Ionizing Radiation-Induced Malformations in Mice

Authors

  • E. Cekan THE DEPARTMENT OF MEDICAL RADIATION BIOLOGY, KAROLINSKA INSTITUTET, 5-10401, STOCKHOLM; THE INSTITUTE OF THEORETICAL PHYSICS, UNIVERSITY OF STOCKHOLM, S-10691, STOCKHOLM, SWEDEN
  • B. Tribukait THE DEPARTMENT OF MEDICAL RADIATION BIOLOGY, KAROLINSKA INSTITUTET, 5-10401, STOCKHOLM; THE INSTITUTE OF THEORETICAL PHYSICS, UNIVERSITY OF STOCKHOLM, S-10691, STOCKHOLM, SWEDEN
  • H. Vokal-Borek THE DEPARTMENT OF MEDICAL RADIATION BIOLOGY, KAROLINSKA INSTITUTET, 5-10401, STOCKHOLM; THE INSTITUTE OF THEORETICAL PHYSICS, UNIVERSITY OF STOCKHOLM, S-10691, STOCKHOLM, SWEDEN

DOI:

https://doi.org/10.3109/02841868509134399

Abstract

A single dose of sodium selenite (0.5 mg Se/kg b.w.) was injected intraperitoneally into mice on day 9 of pregnancy, either 30 min or 2 h before 1.75 Gy whole body irradiation. Administration of selenite 2 h but not 30 min before irradiation resulted in a significant decrease in the number of malformed foetuses (p<0.005). The decrease in foetal malformations occurred proportionally for all the major malformations observed, i.e. short or kinked tail, rib and vertebral malformations, coloboma and deformation of retina and iris. In addition, selenium pretreatment also protected against radiation-induced retardation of the sternum of the foetus.

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Published

1985-01-01

How to Cite

Cekan, E., Tribukait, B., & Vokal-Borek, H. (1985). Protective Effect of Selenium Against Ionizing Radiation-Induced Malformations in Mice. Acta Oncologica, 24(3), 267–271. https://doi.org/10.3109/02841868509134399

Issue

Vol. 24 No. 3 (1985): Acta Radiologica: Oncology

Section

Articles