Invasive Squamous Cell Carcinoma of the Uterine Cervix: IX. Construction of a partial index in a histopathologic malignancy grading system

Abstract

A malignancy grading system (MGS) for invasive squa-mous cell carcinoma of the uterine cervix, consisting of four items for the tumour-cell population and four items for the tumour-host relationship, proved to have a good prognostic capacity. A correlation analysis based on 161 patients with invasive squamous cell carcinoma of the uterine cervix in stages I and II was evaluated. The relationships between survival/lethality ratio (SIL) and all single items, MGS, and a reduced partial index were compared. The study showed good agreement with previous studies on another partial index. The MGS had the best predictive value. The items of the tumour-cell population had no significant predictive value. According to a regression analysis, items for the tumour-host relationship or the items vascular invasion and host-cellular response alone could be used without any substantial loss of predictive capacity compared with the MGS. However, the MGS remains the most complete and adequate classification for invasive squamous cell carcinoma of the uterine cervix.