Accumulation of 99Tcm-Gluconate in Daunorubicin-Treated Neonatal Heart Cells in Culture

Authors

  • D. Galaris THE DEPARTMENT OF BIOCHEMISTRY, ARRHENIUS LABORATORY, UNIVERSITY OF STOCKHOLM, S-10691, STOCKHOLM; THE DEPARTMENT OF DIAGNOSTIC RADIOLOGY, HUDDINGE UNIVERSITY HOSPITAL, S-14186, HUDDINGE, SWEDEN
  • B. Isberg THE DEPARTMENT OF BIOCHEMISTRY, ARRHENIUS LABORATORY, UNIVERSITY OF STOCKHOLM, S-10691, STOCKHOLM; THE DEPARTMENT OF DIAGNOSTIC RADIOLOGY, HUDDINGE UNIVERSITY HOSPITAL, S-14186, HUDDINGE, SWEDEN
  • N.-E. Ahlberg THE DEPARTMENT OF BIOCHEMISTRY, ARRHENIUS LABORATORY, UNIVERSITY OF STOCKHOLM, S-10691, STOCKHOLM; THE DEPARTMENT OF DIAGNOSTIC RADIOLOGY, HUDDINGE UNIVERSITY HOSPITAL, S-14186, HUDDINGE, SWEDEN
  • J. Rydström THE DEPARTMENT OF BIOCHEMISTRY, ARRHENIUS LABORATORY, UNIVERSITY OF STOCKHOLM, S-10691, STOCKHOLM; THE DEPARTMENT OF DIAGNOSTIC RADIOLOGY, HUDDINGE UNIVERSITY HOSPITAL, S-14186, HUDDINGE, SWEDEN

DOI:

https://doi.org/10.3109/02841868509134383

Abstract

The cardiotoxic effect of daunorubicin was investigated using cultured heart cells from neonatal rat hearts. Exposure of the cells to low but toxic concentrations of daunorubicin led to drastically altered permeability properties of the plasma membrane as measured by release of lactate dehydrogenase. Simultaneously, 99Tcm-gluconate, an isotope complex used in scintigraphic imaging of myocar-dial infacts, was accumulated in the cells. The results suggest that daunorubicin-induced cardiac damage may be estimated by isotope uptake.

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Published

1985-01-01

How to Cite

Galaris, D., Isberg, B., Ahlberg, N.-E., & Rydström, J. (1985). Accumulation of 99Tcm-Gluconate in Daunorubicin-Treated Neonatal Heart Cells in Culture. Acta Oncologica, 24(2), 177–180. https://doi.org/10.3109/02841868509134383

Issue

Vol. 24 No. 2 (1985): Acta Radiologica: Oncology

Section

Articles