Whole-Body Autoradiography of 123I-Labelled Islet Amyloid Polypeptide (IAPP) Accumulation in the lung parenchyma and in the villi of the intestinal mucosa in rats

Authors

  • Mats Stridsberg Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
  • Hans Tjalve Departments of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
  • Erik Wilander Department of Pathology, University Hospital, Uppsala, Sweden

DOI:

https://doi.org/10.3109/02841869309083905

Abstract

Islet amyloid polypeptide (IAPP) is a 37 amino-acid pancreatic islet polypeptide, displaying about 50% amino-acid homology with neuropeptide calcitonin gene-related peptide (CGRP). IAPP is co-stored with insulin in the β-cell secretory granules and co-released with insulin Upon stimulation. Human IAPP has the ability to precipitate in the shape of amyloid in patients with typ II (non-insulin dependent) diabetes but otherwise its functional or pathophysiological role is enigmatic. In the present stu these sites.

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Published

1993-01-01

How to Cite

Stridsberg, M., Tjalve, H., & Wilander, E. (1993). Whole-Body Autoradiography of 123I-Labelled Islet Amyloid Polypeptide (IAPP) Accumulation in the lung parenchyma and in the villi of the intestinal mucosa in rats. Acta Oncologica, 32(2), 155–159. https://doi.org/10.3109/02841869309083905

Issue

Vol. 32 No. 2 (1993): Acta Oncologica

Section

Articles