Prevalence of human papillomavirus (HPV) types 16 and 18 in cervical cancer in Stockholm, Sweden during 2019–2023 compared to 2003–2008

Authors

  • Lars Sivars a Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
  • Stefan Holzhauser c Department of Oncology-Pathology Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
  • Torbjörn Ramqvist c Department of Oncology-Pathology Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
  • Emma Tham a Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; b Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
  • Kristina Hellman d Department of Women’s and Children’s Health, Karolinska Institutet, StockholmSweden; e Department of Gynecologic Cancer, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden
  • Tina Dalianis c Department of Oncology-Pathology Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden

DOI:

https://doi.org/10.1080/0284186X.2023.2264485

Keywords:

Cancer of the cervix uteri, HPV types, HPV vaccination

Abstract

Background

The prevalence of different HPV types, especially HPV16 and 18 in cervical cancer in patients diagnosed 2019–2023 in Stockholm was compared to corresponding data from 2003–2008 before the introduction of HPV vaccination in Sweden.

Material and Methods

Cervical cancer samples from 125 patients diagnosed 2019–2023 in Stockholm were analysed for 27 HPV types by multiplex assay and the HPV type prevalence data was compared to data obtained in 154 cervical samples from 2003–2008.

Results

Patient median age was higher 2019–2023 compared to 2003–2008 (55-years vs. 42-years, p = 0.046). Overall HPV prevalence was 93.6%, HPV16 and 18 accounted for 62.2% of all squamous cell carcinoma cases (SCC) and 63.6% of all adenocarcinoma cases (ADC) vs. 92.9%, 69.7% and 88.6% respectively 2003–2008.

Conclusion

The joint prevalence of HPV16 and 18 in SCC and ADC tended to be slightly lower in 2019–2023 as compared to 2003–2008, but the difference was not statistically significant.

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Published

2023-12-02

How to Cite

Sivars, L., Holzhauser, S., Ramqvist, T., Tham, E., Hellman, K., & Dalianis, T. (2023). Prevalence of human papillomavirus (HPV) types 16 and 18 in cervical cancer in Stockholm, Sweden during 2019–2023 compared to 2003–2008. Acta Oncologica, 62(12), 1649–1652. https://doi.org/10.1080/0284186X.2023.2264485

Issue

Vol. 62 No. 12 (2023): Acta Oncologica

Section

Articles