Laryngeal cancer relative survival trends from 1972 to 2021 in the Nordic countries
DOI:
https://doi.org/10.2340/1651-226X.2024.40823Keywords:
laryngeal cancer, larynx, relative survival, head and neck cancerAbstract
Background and purpose: Changes in treatment approaches, characterised by the shift from laryngectomy to a focus on organ-preserving methods may have potentially resulted in lower survival. We aim to identify differences in survival trends for laryngeal cancer (LC) in the Nordic countries over a period of 50 years, and discuss the potential impact of factors such as changes in treatment protocols.
Materials and methods: Five-year relative survival (RS) data from 1972 to 2021 were obtained from the NORDCAN database 2.0 which included 33,692 LC cases, of which 85% were diagnosed among men. In the NORDCAN database, the age-standardised RS is calculated using the Pohar Perme estimator with individual International Cancer Survival Standards weights. Joinpoint regression models were used to assess potential shifts in trend over the years in RS.
Results: While Denmark and Norway demonstrated an increasing trend in 5-year RS from 1972 to 2021, in Finland and Sweden, the 5-year RS among men remained static, without any discernible significant trend. Over the 30-year period from 1992–1996 to 2017–2021, RS improved by 9, 4, 13, and 2 percentage points in Denmark, Finland, Norway, and Sweden, respectively. Among women in Sweden, a linear negative trend was observed, noticeable as a 16 percentage-point decline in 5-year RS from the earliest to the latest period.
Interpretation: The underlying causes for the differences in survival trends remain unclear. Besides differences in treatment protocols, several other factors can affect RS making the interpretation of RS trends challenging.
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References
GLOBOCAN. Global cancer observatory: Cancer today. International Agency for Research on Cancer [Internet]. [cited 2024 May 19]. Availa-ble from: https://gco.iarc.fr/en
Nocini R, Molteni G, Mattiuzzi C, Lippi G. Updates on larynx cancer epidemiology. Chin J Cancer Res. 2020;32:18–25.
https://doi.org/10.21147/j.issn.1000-9604.2020.01.03 DOI: https://doi.org/10.21147/j.issn.1000-9604.2020.01.03
Ciolofan MS, Vlăescu AN, Mogoantă C-A, Ioniță E, Ioniță I, Căpitănescu A-N, et al. Clinical, histological and immunohistochemical evaluation of larynx cancer. Curr Health Sci J. 2017;43:367–375.
Koroulakis A, Agarwal M. Laryngeal cancer [Internet]. Treasure Island, FL: StatPearls Publishing; 2024 [cited 2024 May 19]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526076/
Hollnger PH. Panel discussion: the historical development of laryngectomy. V. A century of progress of laryngectomies in the northern hemisphere. Laryngoscope. 1975;85:322–332.
https://doi.org/10.1288/00005537-197502000-00010 DOI: https://doi.org/10.1288/00005537-197502000-00010
Obid R, Redlich M, Tomeh C. The treatment of laryngeal cancer. Oral Maxillofac Surg Clin North Am. 2019;31:1–11.
https://doi.org/10.1016/j.coms.2018.09.001 DOI: https://doi.org/10.1016/j.coms.2018.09.001
Hoffman HT, Porter K, Karnell LH, Cooper JS, Weber RS, Langer CJ, et al. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 2006;116:1–13.
https://doi.org/10.1097/01.mlg.0000236095.97947.26 DOI: https://doi.org/10.1097/01.mlg.0000236095.97947.26
Larønningen S, Arvidsson G, Bray F, Engholm G, Ervik M, Guðmundsdóttir EM, et al. NORDCAN: Cancer incidence, mortality, prevalence and survival in the Nordic countries, version 9.3 (02.10.2023) [Internet]. Association of the Nordic Cancer Registries. Cancer Registry of Norway. [cited 2024 May 19]. Available from: https://nordcan.iarc.fr/.2023.
Pukkala E, Engholm G, Højsgaard Schmidt LK, Storm H, Khan S, Lambe M, et al. Nordic Cancer Registries – an overview of their procedures and data comparability. Acta Oncol. 2018;57:440–455.
https://doi.org/10.1080/0284186X.2017.1407039 DOI: https://doi.org/10.1080/0284186X.2017.1407039
Cancer Registry of Norway. Nordcan survival methods [Internet]. [cited 2024 May 19]. Available from: https://github.com/CancerRegistryOfNorway/NORDCAN/wiki/nordcansurvival
Corazziari I, Quinn M, Capocaccia R. Standard cancer patient population for age standardising survival ratios. Eur J Cancer. 2004;40:2307–2316.
https://doi.org/10.1016/j.ejca.2004.07.002 DOI: https://doi.org/10.1016/j.ejca.2004.07.002
Brenner H, Arndt V, Gefeller O, Hakulinen T. An alternative approach to age adjustment of cancer survival rates. Eur J Cancer. 2004;40:2317–2322.
https://doi.org/10.1016/j.ejca.2004.07.007 DOI: https://doi.org/10.1016/j.ejca.2004.07.007
Zitricky F, Koskinen AI, Hemminki O, Försti A, Hemminki A, Hemminki K. Survival in oral and pharyngeal cancers is catching up with laryn-geal cancer in the NORDIC countries through a half century. Cancer Med. 2024;13:e6867.
https://doi.org/10.1002/cam4.6867 DOI: https://doi.org/10.1002/cam4.6867
Gatta G, Botta L, Sánchez MJ, Anderson LA, Pierannunzio D, Licitra L, et al. Prognoses and improvement for head and neck cancers diag-nosed in Europe in early 2000s: the EUROCARE-5 population-based study. Eur J Cancer. 2015;51:2130–2143. DOI: https://doi.org/10.1016/j.ejca.2015.07.043
Ellis L, Rachet B, Birchall M, Coleman MP. Trends and inequalities in laryngeal cancer survival in men and women: England and Wales 19912006. Oral Oncol. 2012;48:284–289.
https://doi.org/10.1016/j.oraloncology.2011.10.012 DOI: https://doi.org/10.1016/j.oraloncology.2011.10.012
Tsuge H, Kawakita D, Taniyama Y, Oze I, Koyanagi YN, Hori M, et al. Subsite‐specific trends in mid‐ and long‐term survival for head and neck cancer patients in Japan: a population‐based study. Cancer Sci. 2024;115:623–634.
https://doi.org/10.1111/cas.16028 DOI: https://doi.org/10.1111/cas.16028
Macneil SD, Liu K, Shariff SZ, Thind A, Winquist E, Yoo J, et al. Secular trends in the survival of patients with laryngeal carcinoma, 1995–2007. Curr Oncol. 2015;22:e85–e99.
https://doi.org/10.3747/co.22.2361 DOI: https://doi.org/10.3747/co.22.2361
Li MM, Zhao S, Eskander A, Rygalski C, Brock G, Parikh AS, et al. Stage migration and survival trends in laryngeal cancer. Ann Surg Oncol. 2021;28:7300–7309.
https://doi.org/10.1245/s10434-021-10318-1 DOI: https://doi.org/10.1245/s10434-021-10318-1
Haapaniemi A, Koivunen P, Saarilahti K, Kinnunen I, Laranne J, Aaltonen LM, et al. Laryngeal cancer in Finland: a 5-year follow-up study of 366 patients. Head Neck. 2016;38:36–43.
https://doi.org/10.1002/hed.23834 DOI: https://doi.org/10.1002/hed.23834
Brandstorp-Boesen J, Falk RS, Boysen M, Brøndbo K. Impact of stage, management and recurrence on survival rates in laryngeal cancer. PLoS One. 2017;12:e0179371.
https://doi.org/10.1371/journal.pone.0179371 DOI: https://doi.org/10.1371/journal.pone.0179371
Ryan WR, Fee WE, Le QT, Pinto HA. Positron-emission tomography for surveillance of head and neck cancer. Laryngoscope. 2005;115:645–650.
https://doi.org/10.1097/01.mlg.0000161345.23128.d4 DOI: https://doi.org/10.1097/01.mlg.0000161345.23128.d4
Kim DH, Kim Y, Kim SW, Hwang SH. Use of narrowband imaging for the diagnosis and screening of laryngeal cancer: a systematic review and meta-analysis. Head Neck. 2020;42:2635–2643.
https://doi.org/10.1002/hed.26186 DOI: https://doi.org/10.1002/hed.26186
Engholm G, Lundberg FE, Kønig SM, Ólafsdóttir E, Johannesen TB, Pettersson D, et al. TNM stage in the Nordic Cancer Registries 2004–2016: registration and availability. Acta Oncol. 2024;63:303–312.
https://doi.org/10.2340/1651-226X.2024.35232 DOI: https://doi.org/10.2340/1651-226X.2024.35232
Hinni ML, Salassa JR, Grant DG, Pearson BW, Hayden RE, Martin A, et al. Transoral laser microsurgery for advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg. 2007;133:1198–1204.
https://doi.org/10.1001/archotol.133.12.1198 DOI: https://doi.org/10.1001/archotol.133.12.1198
Lindholm C-E, Elner A. Transoral laser surgery of laryngeal carcinomas. State of the art in Sweden. Adv Otorhinolaryngol. 1995;49:250–253.
https://doi.org/10.1159/000424384 DOI: https://doi.org/10.1159/000424384
Al-Mamgani A, van Rooij PH, Woutersen DP, Mehilal R, Tans L, Monserez D, et al. Radiotherapy for T1-2N0 glottic cancer: a multivariate analysis of predictive factors for the long-term outcome in 1050 patients and a prospective assessment of quality of life and voice handicap index in a subset of 233 patients. Clin Otolaryngol. 2013;38:306–312.
https://doi.org/10.1111/coa.12139 DOI: https://doi.org/10.1111/coa.12139
Wang X, Hu C, Eisbruch A. Organ-sparing radiation therapy for head and neck cancer. Nat Rev Clin Oncol. 2011;8:639–648.
https://doi.org/10.1038/nrclinonc.2011.106 DOI: https://doi.org/10.1038/nrclinonc.2011.106
Department of Veterans Affairs Laryngeal Cancer Study Group, Wolf GT, Fisher SG, Hong WK, Hillman R, Spaulding M, et al. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991;324:1685–1690.
https://doi.org/10.1056/NEJM199106133242402 DOI: https://doi.org/10.1056/NEJM199106133242402
Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, et al. Concurrent chemotherapy and radiotherapy for organ preser-vation in advanced laryngeal cancer. N Engl J Med. 2003;349:2091–2098.
https://doi.org/10.1056/NEJMoa031317 DOI: https://doi.org/10.1056/NEJMoa031317
Blomkvist R, Marklund L, Hammarstedt-Nordenvall L, Gottlieb-Vedi E, Mäkitie A, Palmgren B. Treatment and outcome among patients with laryngeal squamous cell carcinoma in Stockholm – a population‐based study. Laryngoscope Investig Otolaryngol. 2023;8:441–449.
https://doi.org/10.1002/lio2.1034 DOI: https://doi.org/10.1002/lio2.1034
Wærsted S, Andersen E, Bentzen J. Treatment outcomes in patients with supraglottic laryngeal cancer: a single centre study. Acta Oto-laryngol. 2021;141:649–655.
https://doi.org/10.1080/00016489.2021.1910729 DOI: https://doi.org/10.1080/00016489.2021.1910729
Lyhne NM, Johansen J, Kristensen CA, Andersen E, Primdahl H, Andersen LJ, et al. Incidence of and survival after glottic squamous cell carcinoma in Denmark from 1971 to 2011 – a report from the Danish Head and Neck Cancer Group. Eur J Cancer. 2016;59:46–56.
https://doi.org/10.1016/j.ejca.2016.01.020 DOI: https://doi.org/10.1016/j.ejca.2016.01.020
Sun L, Brody R, Candelieri D, Lynch JA, Cohen RB, Li Y, et al. Risk of cardiovascular events among patients with head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2023;149:717–725.
https://doi.org/10.1001/jamaoto.2023.1342 DOI: https://doi.org/10.1001/jamaoto.2023.1342
Dreyer L, Winther JF, Pukkala E, Andersen A. Tobacco smoking. APMIS. 1997;105:9–47.
https://doi.org/10.1111/j.1600-0463.1997.tb05609.x DOI: https://doi.org/10.1111/j.1600-0463.1997.tb05609.x
Rachidi S, Wallace K, Day TA, Alberg AJ, Li Z. Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma. J Hematol Oncol. 2014;7:65.
https://doi.org/10.1186/s13045-014-0065-5 DOI: https://doi.org/10.1186/s13045-014-0065-5
Wüster J, Heiland M, Nahles S, Preissner R, Preissner S. Statin medication improves five-year survival rates in patients with head and neck cancer: a retrospective case-control study of about 100,000 patients. Cancers (Basel). 2023;15:3093.
https://doi.org/10.3390/cancers15123093 DOI: https://doi.org/10.3390/cancers15123093
Hoffman SN, TenBrook JA, Wolf MP, Pauker SG, Salem DN, Wong JB. A meta-analysis of randomized controlled trials comparing coronary artery bypass graft with percutaneous transluminal coronary angioplasty: one- to eight-year outcomes. J Am Coll Cardiol. 2003;41:1293–1304.
https://doi.org/10.1016/S0735-1097(03)00157-8 DOI: https://doi.org/10.1016/S0735-1097(03)00157-8
Koskinen A, Hemminki O, Försti A, Hemminki K. Incidence and survival in laryngeal and lung cancers in Finland and Sweden through a half century. PLoS One. 2022;17:e0268922.
https://doi.org/10.1371/journal.pone.0268922 DOI: https://doi.org/10.1371/journal.pone.0268922
Nordic Council of Ministers. Nordic Statistical Yearbook 2007. Copenhagen: Nordic Council of Ministers; 2007.
Storm HH, Engholm G, Hakulinen T, Tryggvadóttir L, Klint Å, Gislum M, et al. Survival of patients diagnosed with cancer in the Nordic countries up to 1999–2003 followed to the end of 2006. A critical overview of the results. Acta Oncol. 2010;49:532–544.
https://doi.org/10.3109/02841861003801148 DOI: https://doi.org/10.3109/02841861003801148
Knudsen AK, Allebeck P, Tollånes MC, Skogen JC, Iburg KM, McGrath JJ, et al. Life expectancy and disease burden in the Nordic countries: results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. Lancet Public Health. 2019;4:e658–e669. DOI: https://doi.org/10.1016/S2468-2667(19)30224-5
Cancer Society of Finland. Finnish Cancer Registry. Cancer statistics [Internet]. [cited 2024 May 19]. Available from: https://cancerregistry.fi/statistics/cancer-statistics/
Gjerstorff ML. The Danish Cancer Registry. Scand J Public Health. 2011;39:42–45. DOI: https://doi.org/10.1177/1403494810393562
Larsen IK, Småstuen M, Johannesen TB, Langmark F, Parkin DM, Bray F, et al. Data quality at the Cancer Registry of Norway: an overview of comparability, completeness, validity and timeliness. Eur J Cancer. 2009;45:1218–1231.
https://doi.org/10.1016/j.ejca.2008.10.037 DOI: https://doi.org/10.1016/j.ejca.2008.10.037
Teppo L, Pukkala E, Lehtonen M. Data quality and quality control of a population-based cancer registry. Experience in Finland. Acta Oncol. 1994;33:365–369.
https://doi.org/10.3109/02841869409098430 DOI: https://doi.org/10.3109/02841869409098430
Barlow L, Westergren K, Holmberg L, Tälback M. The completeness of the Swedish Cancer Register: a sample survey for year 1998. Acta Oncol. 2009;48:27–33.
https://doi.org/10.1080/02841860802247664 DOI: https://doi.org/10.1080/02841860802247664
Mork J, Thoresen S, Faye-Lund H, Langmark F, Glattre E. Head and neck cancer in Norway. A study of the quality of the Cancer Registry of Norway’s data on head and neck cancer for the period 1953–1991. APMIS. 1995;103:375–382.
https://doi.org/10.1111/j.1699-0463.1995.tb01121.x
Bui AT, Yong Ji KS, Pham CT, Le KM, Tong TX, Lee WT. Longitudinal evaluation of quality of life in Laryngeal Cancer patients treated with surgery. Int J Surg. 2018;58:65–70. DOI: https://doi.org/10.1016/j.ijsu.2018.09.011
https://doi.org/10.1111/j.1699-0463.1995.tb01121.x DOI: https://doi.org/10.1111/j.1699-0463.1995.tb01121.x
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