Effect of high-density fat combined with adipose stem cell glue on the success rate of facial filling and its clinical value

Junsheng Xu; Yu Zhao

doi:10.2340/jphs.v59.18683

Authors

Junsheng Xu Hefei BOE Hospital, Hefei City, Anhui Province, China
Yu Zhao The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China https://orcid.org/0009-0000-0575-2306

DOI:

https://doi.org/10.2340/jphs.v59.18683

Keywords:

High density fat, Adipose stem cell glue, Success rate of facial filling, Life quality, Complications

Abstract

Facial fat grafting is a popular cosmetic procedure, and experts are increasingly endorsing the use of high-density fat with adipose stem cell glue for better results. This study aims to explore the effect of high-density fat combined with adipose stem cell glue on the success rate of facial filling and its clinical value. We conducted a randomized trial with 100 patients who underwent facial fat transplantation between August 2020 and August 2022. They were divided into two groups: a control group receiving traditional Coleman fat transplantation and an observation group receiving high-density fat with adipose stem cells. In the observation and control groups, the excellent and good rate was 98.00 and 80.00%. After 3 months of treatment, the thickness of frontal subcutaneous fat and temporal subcutaneous fat in the observation group was higher (P < 0.05). Observation group retention of fat transplantation was noticeably higher 3 months after treatment (P < 0.05). Three months after treatment, the VISIA (facial imaging system) scores of facial color spots, facial pores and facial wrinkles in the observation group were lower (P < 0.05). After treatment, both groups indicated noticeable improvements in physiological functions, health status, social function, mental health, and somatic diseases compared to before treatment. Notably, the observation group had higher scores (P < 0.05). The observation group had a lower complication rate (4.00% vs. 22.00%) and higher satisfaction rate (98.00% vs. 86.00%) than the control group. Using high-density fat combined with adipose stem cell glue for facial fat grafting yields superior results, reduces complications, and boosts patient satisfaction compared to traditional methods. We have complied with all relevant ethical regulations with regard to the use of stem cells.

Downloads

Download data is not yet available.

References

Tonnard P, Verpaele A, Carvas M. Fat grafting for facial rejuvenation with nanofat grafts. Clin Plast Surg. 2020; 47(1): 53–62.https://doi.org/10.1016/j.cps.2019.08.006 DOI: https://doi.org/10.1016/j.cps.2019.08.006

Hicks KE, Thomas JR. The changing face of beauty: a global assessment of facial beauty. Otolaryngol Clin North Am. 2020; 53(2): 185–194.

https://doi.org/10.1016/j.otc.2019.12.005 DOI: https://doi.org/10.1016/j.otc.2019.12.005

Azoury SC, Shakir S, Bucky LP, Percec I. Modern fat grafting techniques to the face and neck. Plast Reconstr Surg. 2021; 148(4): 620e–633e.

https://doi.org/10.1097/PRS.0000000000008405 DOI: https://doi.org/10.1097/PRS.0000000000008405

Chouikh F, Dierks EJ. The buccal fat pad flap. Oral Maxillofac Surg Clin North Am. 2021; 33(2): 177–184. DOI: https://doi.org/10.1016/j.coms.2020.12.005

https://doi.org/10.1016/

j.coms.2020.12.005 DOI: https://doi.org/10.1088/1475-7516/2020/12/005

Felix Bravo B, Bezerra de Menezes Penedo L, de Melo Carvalho R, et al. Improvement of facial skin laxity by a combined tech-nique with hyaluronic acid and calcium hydroxylapatite fillers: a clinical and ultrasonography analysis. J Drugs Der-matol. 2022; 21(1): 102–106. DOI: https://doi.org/10.36849/JDD.6333

https://doi.org/10.36849/JDD.2022.6333

Dhooghe NS, Maes S, Depypere B, et al. Fat embolism after autologous facial fat grafting. Aesthet Surg J. 2022; 42(3): 231–238.

https://doi.org/10.1093/asj/sjab252 DOI: https://doi.org/10.1093/asj/sjab252

Ohashi M. Fat grafting for facial rejuvenation with cryopreserved fat grafts. Clin Plast Surg. 2020; 47(1): 63–71.

https://doi.org/10.1016/j.cps.2019.08.007 DOI: https://doi.org/10.1016/j.cps.2019.08.007

Lana J, Lana A, da Fonseca LF, et al. Stromal vascular fraction for knee osteoarthritis – an update. J Stem Cells Regen Med. 2022; 18(1): 11–20.

https://doi.org/10.46582/jsrm.1801003 DOI: https://doi.org/10.46582/jsrm.1801003

Pu LLQ. Fat grafting for facial rejuvenation: my preferred approach. Clin Plast Surg. 2020; 47(1): 19–29.

https://doi.org/10.1016/j.cps.2019.08.002 DOI: https://doi.org/10.1016/j.cps.2019.08.002

Ude CC, Shah S, Ogueri KS, et al. Stromal vascular fraction for osteoarthritis of the knee regenerative engineering. Regen Eng Transl Med. 2022; 8(2): 210–224.

https://doi.org/10.1007/s40883-021-00226-x DOI: https://doi.org/10.1007/s40883-021-00226-x

Vargel I, Tuncel A, Baysal N, et al. Autologous adipose-derived tissue stromal vascular fraction (AD-tSVF) for knee osteoar-thritis. Int J Mol Sci. 2022; 23: 13517.

https://doi.org/10.3390/ijms232113517 DOI: https://doi.org/10.3390/ijms232113517

Sisti A, Boczar D, Forte AJ. Fat injection in facial artery. JAMA Facial Plast Surg. 2019; 21(2): 171.

https://doi.org/10.1001/jamafacial.2018.1320 DOI: https://doi.org/10.1001/jamafacial.2018.1320

Raposio E, Ciliberti R. Clinical use of adipose-derived stem cells: European legislative issues. Ann Med Surg. 2017; 24: 61–64.

https://doi.org/10.1016/j.amsu.2017.11.002 DOI: https://doi.org/10.1016/j.amsu.2017.11.002

Yin T, Zhao X. Efficacy and safety of nano-fat combined with high-density fat transplantation in facial cosmetic surgery. Cosmet Med China. 2020; 29(12): 75–78.

Holcomb JD. Helium plasma dermal resurfacing: VISIA CR assessment of facial spots, pores, and wrinkles-Preliminary find-ings. J Cosmet Dermatol. 2021; 20(6): 1668–1678.

https://doi.org/10.1111/jocd.14106 DOI: https://doi.org/10.1111/jocd.14106

Hersnaes PN, Gromov K, Otte KS, et al. Harris Hip Score and SF-36 following metal-on-metal total hip arthroplasty and hip resurfacing – a randomized controlled trial with 5-years follow up including 75 patients. BMC Musculoskelet Disord. 2021; 22(1): 781.

https://doi.org/10.1186/s12891-021-04671-1 DOI: https://doi.org/10.1186/s12891-021-04671-1

Prescher H, Hanson SE. Commentary on: supplementation of facial fat grafting to increase volume retention: a systematic review. Aesthet Surg J. 2022; 42(12): NP728–9.

https://doi.org/10.1093/asj/sjac184 DOI: https://doi.org/10.1093/asj/sjac184

Paulucci BP. PMMA safety for facial filling: review of rates of granuloma occurrence and treatment methods. Aesthetic Plast Surg. 2020; 44(1): 148–59.

https://doi.org/10.1007/s00266-019-01522-2 DOI: https://doi.org/10.1007/s00266-019-01522-2

Brooker JE, Rubin JP, Marra KG. The future of facial fat grafting. J Craniofac Surg. 2019; 30(3): 644–651.

https://doi.org/10.1097/SCS.0000000000005274 DOI: https://doi.org/10.1097/SCS.0000000000005274

Ueberreiter CS, Ueberreiter K, Mohrmann C, et al. [Long-term evaluation after autologous fat transplantation for breast augmentation]. Handchir Mikrochir Plast Chir. 2021; 53(2): 149–158.

https://doi.org/10.1055/a-1183-4338 DOI: https://doi.org/10.1055/a-1183-4338

Delay E. Commentary on: autologous fat transplantation for aesthetic breast augmentation: a systematic review and meta-analysis. Aesthet Surg J. 2021; 41(6): NP430–2.

https://doi.org/10.1093/asj/sjaa419 DOI: https://doi.org/10.1093/asj/sjaa419

Allen RJ, Jr, Canizares O, Jr, Scharf C, et al. Grading lipoaspirate: is there an optimal density for fat grafting? Plast Reconstr Surg. 2013; 131(1): 38–45.

https://doi.org/10.1097/PRS.0b013e3182729cc6 DOI: https://doi.org/10.1097/PRS.0b013e3182729cc6

Tuin AJ, Schepers RH, Spijkervet FKL, et al. Volumetric effect and patient satisfaction after facial fat grafting. Plast Reconstr Surg. 2022; 150(2): 307e–318e.

https://doi.org/10.1097/PRS.0000000000009337 DOI: https://doi.org/10.1097/PRS.0000000000009337

Gontijo-de-Amorim NF, Charles-de-Sa L, Rigotti G. Fat grafting for facial contouring using mechanically stromal vascular fraction-enriched lipotransfer. Clin Plast Surg. 2020; 47(1): 99–109.

https://doi.org/10.1016/j.cps.2019.08.012 DOI: https://doi.org/10.1016/j.cps.2019.08.012

Stuzin JM, Rohrich RJ, Dayan E. The facial fat compartments revisited: clinical relevance to subcutaneous dissection and facial deflation in face lifting. Plast Reconstr Surg. 2019; 144(5): 1070–1078.

https://doi.org/10.1097/PRS.0000000000006181 DOI: https://doi.org/10.1097/PRS.0000000000006181

Cohen SR, Womack H, Ghanem A. Fat grafting for facial rejuvenation through injectable tissue replacement and regenera-tion: a differential, standardized, anatomic approach. Clin Plast Surg. 2020; 47(1): 31–41. DOI: https://doi.org/10.1016/j.cps.2019.08.005

https://doi.org/10.1016/

j.cps.2019.08.005 DOI: https://doi.org/10.1088/1475-7516/2019/08/005

Schipper JAM, Vriend L, Tuin AJ, et al. Supplementation of facial fat grafting to increase volume retention: a systematic re-view. Aesthet Surg J. 2022; 42(12): NP711–27.

https://doi.org/10.1093/asj/sjac122 DOI: https://doi.org/10.1093/asj/sjac122

Egro FM, Coleman SR. Facial fat grafting: the past, present, and future. Clin Plast Surg. 2020; 47(1): 1–6.

https://doi.org/10.1016/j.cps.2019.08.004 DOI: https://doi.org/10.1016/j.cps.2019.08.004

Heller L, Menashe S, Plonski L, et al. 1470-nm radial fiber-assisted liposuction for body contouring and facial fat grafting. J Cosmet Dermatol. 2022; 21(4): 1514–1522.

https://doi.org/10.1111/jocd.14767 DOI: https://doi.org/10.1111/jocd.14767

Denadai R, Buzzo CL, Raposo-Amaral CA, et al. Facial contour symmetry outcomes after site-specific facial fat compartment augmentation with fat grafting in facial deformities. Plast Reconstr Surg. 2019; 143(2): 544–556. DOI: https://doi.org/10.1097/PRS.0000000000005220

https://doi.org

Cohen SR, Wesson J, Willens S, et al. Standardized anatomic and regenerative facial fat grafting: objective photometric evalu-ation 1 to 19 months after injectable tissue replacement and regeneration. Aesthet Surg J. 2022; 42(4): 327–339.

https://doi.org/10.1093/asj/sjab379 DOI: https://doi.org/10.1093/asj/sjab379