Current materials and techniques in cosmetic hand injections
DOI:
https://doi.org/10.2340/jphs.v61.45435Keywords:
hand, injections, rejuvenationAbstract
Background: With the widespread popularity and development of aesthetic treatments, the focus has extended from facial aging to include the aging of hands. The primary aim of this study is to review the current materials, methods of injection, and testing procedures employed in cosmetic hand injections.
Methods: PubMed database (from 1971 to April 2024) was searched to identify relevant studies on materials, injection techniques, and evaluation methods associated with aesthetic hand injections, excluding systematic reviews and medical record reports.
Results: A total of 1815 articles were identified, of which 41 articles were included. This study summarizes the current materials, injection techniques, and outcome evaluation methods used for cosmetic hand injections, while discussing observations and making recommendations.
Conclusion: Hand skin conditions tend to receive less attention than cosmetic facial injections. In existing studies of injected substances, hydroxyapatite remains the main material used for cosmetic hand injections. Poly-L-lactic acid (PLLA), platelet-rich plasma (PRP), and polycaprolactone injections were significantly more effective than other substances in the hand. In commonly used injection techniques, catheter-based injection methods are more accurate than needle positioning and dose. The most commonly used assessment methods remain ultrasound and the Merz hand partial scale. At present, there is still a relative lack of research on aesthetic hand injections, and extensive and in-depth research, such as randomized studies comparing hyaluronic acid and calcium hydroxylapatite and longitudinal data on the results of PLLA or PRP, is recommended to further develop hand injection techniques with lasting aesthetic results. Increased public awareness of hand injections derives from more reliable and valid studies. And we need standardized outcome measures and long-term follow-up data in future studies.
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References
Moradi A, Allen S, Bank D, et al. A prospective, multicenter, randomized, evaluator-blinded, split-hand study to evaluate the effectiveness and safety of large-gel-particle hyaluronic acid with lidocaine for the correction of volume deficits in the dorsal hand. Plast Reconstr Surg. 2019;144(4):586e–596e.
https://doi.org/10.1097/PRS.0000000000006070 DOI: https://doi.org/10.1097/PRS.0000000000006070
[Fabi SG, Goldman MP. Hand rejuvenation: a review and our experience. Dermatol Surg. 2012;38(7 Pt 2):1112–1127.
https://doi.org/10.1111/j.1524-4725.2011.02291.x DOI: https://doi.org/10.1111/j.1524-4725.2011.02291.x
Bidic SM, Hatef DA, Rohrich RJ. Dorsal hand anatomy relevant to volumetric rejuvenation. Plast Reconstr Surg. 2010;126(1):163–168.
https://doi.org/10.1097/PRS.0b013e3181da86ee DOI: https://doi.org/10.1097/PRS.0b013e3181da86ee
Bains RD, Thorpe H, Southern S. Hand aging: patients’ opinions. Plast Reconstr Surg. 2006;117(7):2212–2218.
https://doi.org/10.1097/01.prs.0000218712.66333.97 DOI: https://doi.org/10.1097/01.prs.0000218712.66333.97
Fathi R, Cohen JL. Challenges, considerations, and strategies in hand rejuvenation. J Drugs Dermatol. 2016;15(7):809–815.
Hung YT, Cheng CY, Chen CB, Huang YL. Ultrasound analyses of the dorsal hands for volumetric rejuvenation. Aesthet Surg J. 2022;42(10):1119–1126.
https://doi.org/10.1093/asj/sjac035 DOI: https://doi.org/10.1093/asj/sjac035
Eberlin KR, Chang J, Curtin CM, Sammer DM, Saint-Cyr M, Taghinia AH. Soft-tissue coverage of the hand: a case-based approach. Plast Reconstr Surg. 2014;133(1):91–101.
https://doi.org/10.1097/01.prs.0000436831.73323.88 DOI: https://doi.org/10.1097/01.prs.0000436831.73323.88
Butterwick KJ. Lipoaugmentation for aging hands: a comparison of the longevity and aesthetic results of centrifuged versus noncentrifuged fat. Dermatol Surg. 2002;28(11):987–991. DOI: https://doi.org/10.1046/j.1524-4725.2002.02096.x
https://doi.org/10.1097/00042728-200211000-00003 DOI: https://doi.org/10.1097/00042728-200211000-00003
Redaelli A. Cosmetic use of polylactic acid for hand rejuvenation: report on 27 patients. J Cosmet Dermatol. 2006;5(3):233–238.
https://doi.org/10.1111/j.1473-2165.2006.00259.x DOI: https://doi.org/10.1111/j.1473-2165.2006.00259.x
Abergel RP, David LM. Aging hands: a technique of hand rejuvenation by laser resurfacing and autologous fat transfer. J Dermatol Surg Oncol. 1989;15(7):725–728.
https://doi.org/10.1111/j.1524-4725.1989.tb03619.x DOI: https://doi.org/10.1111/j.1524-4725.1989.tb03619.x
Kim JS. Detailed sonographic anatomy of dorsal hand augmentation with hyaluronic acid and calcium hydroxyapatite fillers. Aesthet Surg J. 2019;39(10):1096–1106.
https://doi.org/10.1093/asj/sjy227 DOI: https://doi.org/10.1093/asj/sjy227
Guida S, Galadari H. A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for treatment of the face. Int J Dermatol. 2024;63(2):150–160.
https://doi.org/10.1111/ijd.16888 DOI: https://doi.org/10.1111/ijd.16888
Fallacara A, Manfredini S, Durini E, Vertuani S. Hyaluronic acid fillers in soft tissue regeneration. Facial Plast Surg. 2017;33(1):87–96.
https://doi.org/10.1055/s-0036-1597685 DOI: https://doi.org/10.1055/s-0036-1597685
Greene JJ, Sidle DM. The hyaluronic acid fillers: current understanding of the tissue device interface. Facial Plast Surg Clin North Am. 2015;23(4):423–432.
https://doi.org/10.1016/j.fsc.2015.07.002 DOI: https://doi.org/10.1016/j.fsc.2015.07.002
Wilkerson EC, Goldberg DJ. Small-particle hyaluronic acid gel treatment of photoaged hands. Dermatol Surg. 2018;44(1):68–74.
https://doi.org/10.1097/DSS.0000000000001251 DOI: https://doi.org/10.1097/DSS.0000000000001251
Wu Y, Tian Y, Xu J, Zhong S, Wang R, Wu W. A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population. J Cosmet Dermatol. 2020;19(7):1627–1635.
https://doi.org/10.1111/jocd.13221 DOI: https://doi.org/10.1111/jocd.13221
Brandt FS, Cazzaniga A, Strangman N, Coleman J, Axford-Gatley R. Long-term effectiveness and safety of small gel particle hyaluronic acid for hand rejuvenation. Dermatol Surg. 2012;38(7 Pt 2):1128–1135.
https://doi.org/10.1111/j.1524-4725.2011.02282.x DOI: https://doi.org/10.1111/j.1524-4725.2011.02282.x
Williams S, Tamburic S, Stensvik H, Weber M. Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands. J Cosmet Dermatol. 2009;8(3):216–225.
https://doi.org/10.1111/j.1473-2165.2009.00447.x DOI: https://doi.org/10.1111/j.1473-2165.2009.00447.x
Gubanova EI, Starovatova PA, Rodina MY. 12-month effects of stabilized hyaluronic acid gel compared with saline for rejuvenation of aging hands. J Drugs Dermatol. 2015;14(3):288–298.
Agerup B, Berg P, Akermark C. Non-animal stabilized hyaluronic acid: a new formulation for the treatment of osteoarthritis. BioDrugs. 2005;19(1):23–30.
https://doi.org/10.2165/00063030-200519010-00003 DOI: https://doi.org/10.2165/00063030-200519010-00003
Kumar V, Jain A, Atre S, et al. Non-surgical rhinoplasty using hyaluronic acid dermal fillers: a systematic review. J Cosmet Dermatol. 2021;20(8):2414–2424.
https://doi.org/10.1111/jocd.14173 DOI: https://doi.org/10.1111/jocd.14173
Streker M, Reuther T, Krueger N, Kerscher M. Stabilized hyaluronic acid-based gel of non-animal origin for skin rejuvenation: face, hand, and décolletage. J Drugs Dermatol. 2013;12(9):990–994.
Man J, Rao J, Goldman M. A double-blind, comparative study of nonanimal-stabilized hyaluronic acid versus human collagen for tissue augmentation of the dorsal hands. Dermatol Surg. 2008;34(8):1026–1031.
https://doi.org/10.1111/j.1524-4725.2008.34201.x DOI: https://doi.org/10.1111/j.1524-4725.2008.34201.x
Yi KH, Winayanuwattikun W, Kim SY, et al. Skin boosters: definitions and varied classifications. Skin Res Technol. 2024;30(3):e13627.
https://doi.org/10.1111/srt.13627 DOI: https://doi.org/10.1111/srt.13627
Wang F, Garza LA, Kang S, et al. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol. 2007;143(2):155–163.
https://doi.org/10.1001/archderm.143.2.155 DOI: https://doi.org/10.1001/archderm.143.2.155
Leclère FM, Vögelin E, Mordon S, et al. Nonanimal stabilized hyaluronic acid for tissue augmentation of the dorsal hands: a prospective study on 38 patients. Aesthetic Plast Surg. 2012;36(6):1367–1375.
https://doi.org/10.1007/s00266-012-9974-2 DOI: https://doi.org/10.1007/s00266-012-9974-2
Cristel RT, Demesh D, Lombard R, et al. Blinded evaluation of hyaluronic acid hand filler injections and effects on first impressions. Dermatol Surg. 2021;47(5):637–640.
https://doi.org/10.1097/DSS.0000000000002691 DOI: https://doi.org/10.1097/DSS.0000000000002691
Goldman MP, Moradi A, Gold MH, et al. Calcium hydroxylapatite dermal filler for treatment of dorsal hand volume loss: results from a 12-month, multicenter, randomized, blinded trial. Dermatol Surg. 2018;44(1):75–83.
https://doi.org/10.1097/DSS.0000000000001203 DOI: https://doi.org/10.1097/DSS.0000000000001203
Kim JS, Lee W, Oh W, Park JA, Yang EJ. Identification of a suitable layer for injecting calcium hydroxylapatite fillers in the hands. J Plast Reconstr Aesthet Surg. 2021;74(4):866–873.
https://doi.org/10.1016/j.bjps.2020.10.027 DOI: https://doi.org/10.1016/j.bjps.2020.10.027
Figueredo VO, Miot HA, Soares Dias J, Nunes G, Barros de Souza M, Bagatin E. Efficacy and safety of 2 injection techniques for hand biostimulatory treatment with diluted calcium hydroxylapatite. Dermatol Surg. 2020;46(Suppl 1):S54–S61.
https://doi.org/10.1097/DSS.0000000000002334 DOI: https://doi.org/10.1097/DSS.0000000000002334
Moradi A, Ðaković R, Odena G. Aesthetic implantation of calcium hydroxylapatite does not interfere with radiological assessment of bones in the dorsum of the hands. Aesthet Surg J. 2023;43(6):696–703.
https://doi.org/10.1093/asj/sjac344 DOI: https://doi.org/10.1093/asj/sjac344
Lim A, Mulcahy A. Hand rejuvenation: combining dorsal veins foam sclerotherapy and calcium hydroxylapatite filler injections. Phlebology. 2017;32(6):397–402.
https://doi.org/10.1177/0268355516655684 DOI: https://doi.org/10.1177/0268355516655684
Wu DC, Goldman MP. Randomized, double-blinded, sham-controlled, split-hand trial evaluating the safety and efficacy of triamcinolone acetate injection after calcium hydroxylapatite volume restoration of the dorsal hand. Dermatol Surg. 2018;44(4):534–541.
https://doi.org/10.1097/DSS.0000000000001325 DOI: https://doi.org/10.1097/DSS.0000000000001325
Fakih-Gomez N, Kadouch J. Combining calcium hydroxylapatite and hyaluronic acid fillers for aesthetic indications: efficacy of an innovative hybrid filler. Aesthetic Plast Surg. 2022;46(1):373–381.
https://doi.org/10.1007/s00266-021-02479-x DOI: https://doi.org/10.1007/s00266-021-02479-x
Lemperle G, Knapp TR, Sadick NS, Lemperle SM. ArteFill permanent injectable for soft tissue augmentation: I. Mechanism of action and injection techniques. Aesthetic Plast Surg. 2010;34(3):264–272.
https://doi.org/10.1007/s00266-009-9413-1 DOI: https://doi.org/10.1007/s00266-009-9413-1
Kühne U, Imhof M. Treatment of the ageing hand with dermal fillers. J Cutan Aesthet Surg. 2012;5(3):163–169.
https://doi.org/10.4103/0974-2077.101369 DOI: https://doi.org/10.4103/0974-2077.101369
Hirche C, Senghaas A, Fischer S, Hollenbeck ST, Kremer T, Kneser U. Novel use of a flowable collagen-glycosaminoglycan matrix (Integra™ Flowable ound Matrix) combined with percutaneous cannula scar tissue release in treatment of post-burn malfunction of the hand – a preliminary 6 month follow-up. Burns. 2016;42(1):e1–e7.
https://doi.org/10.1016/j.burns.2015.10.013 DOI: https://doi.org/10.1016/j.burns.2015.10.013
Yeh LC, Goldberg DJ. Twelve-month prospective study of polymethylmethacrylate/collagen dermal filler for volume loss of the dorsal of hands. J Cosmet Dermatol. 2020;19(9):2259–2266.
https://doi.org/10.1111/jocd.13445 DOI: https://doi.org/10.1111/jocd.13445
Peng GL. Platelet-rich plasma for skin rejuvenation: facts, fiction, and pearls for practice. Facial Plast Surg Clin North Am. 2019;27(3):405–411.
https://doi.org/10.1016/j.fsc.2019.04.006 DOI: https://doi.org/10.1016/j.fsc.2019.04.006
Pincelli T, Zawawi S, Shapiro S, et al. A pilot, randomized, single-blind, controlled study evaluating the use of platelet rich plasma (PRP) for hand skin rejuvenation. Plast Reconstr Surg. 2024;154(4):727–734.
https://doi.org/10.1097/PRS.0000000000011164 DOI: https://doi.org/10.1097/PRS.0000000000011164
Cabrera-Ramírez JO, Puebla-Mora AG, González-Ojeda A, et al. Platelet-rich plasma for the treatment of photodamage of the skin of the hands. Actas Dermosifiliogr. 2017;108(8):746–751. DOI: https://doi.org/10.1016/j.adengl.2017.07.002
https://doi.org/10.1016/j.ad.2017.04.006 DOI: https://doi.org/10.1016/j.ad.2017.04.006
Sasaki GH. A preliminary clinical trial comparing split treatments to the face and hand with autologous fat grafting and platelet-rich plasma (PRP): a 3D, IRB-approved study. Aesthet Surg J. 2019;39(6):675–686.
https://doi.org/10.1093/asj/sjy254 DOI: https://doi.org/10.1093/asj/sjy254
Christen MO. Collagen stimulators in body applications: a review focused on poly-L-lactic acid (PLLA). Clin Cosmet Investig Dermatol. 2022;15:997–1019.
https://doi.org/10.2147/CCID.S359813 DOI: https://doi.org/10.2147/CCID.S359813
Rendon MI, Cardona LM, Pinzon-Plazas M. Treatment of the aged hand with injectable poly-l-lactic acid. J Cosmet Laser Ther. 2010;12(6):284–287.
https://doi.org/10.3109/14764172.2010.538410 DOI: https://doi.org/10.3109/14764172.2010.538410
Jabbar A, Arruda S, Sadick N. Off face usage of poly-L-lactic acid for body rejuvenation. J Drugs Dermatol. 2017;16(5):489–494.
Vleggaar D. Soft-tissue augmentation and the role of poly-L-lactic acid. Plast Reconstr Surg. 2006;118(3 Suppl):46S–54S.
https://doi.org/10.1097/01.prs.0000234846.00139.74 DOI: https://doi.org/10.1097/01.prs.0000234846.00139.74
Lowe NJ, Ghanem AM. Volume restoration of hands with polycaprolactone by cannula delivery; a prospective single center consecutive case series evaluation. J Cosmet Laser Ther. 2020;22(2):55–59.
https://doi.org/10.1080/14764172.2019.1711127 DOI: https://doi.org/10.1080/14764172.2019.1711127
Noland ME, Lalonde DH, Yee GJ, Rohrich RJ. Current uses of botulinum neurotoxins in plastic surgery. Plast Reconstr Surg. 2016;138(3):519e–530e.
https://doi.org/10.1097/PRS.0000000000002480 DOI: https://doi.org/10.1097/PRS.0000000000002480
Kalliainen LK, O’Brien VH. Current uses of botulinum toxin A as an adjunct to hand therapy interventions of hand conditions. J Hand Ther. 2014;27(2):85–94; quiz 95.
https://doi.org/10.1016/j.jht.2013.12.003 DOI: https://doi.org/10.1016/j.jht.2013.12.003
Lungu C, Nmashie A, George MC, et al. Comparison of ultrasound and electrical stimulation guidance for onabotulinum toxin-A injections: a randomized crossover study. Mov Disord Clin Pract. 2022;9(8):1055–1061.
https://doi.org/10.1002/mdc3.13546 DOI: https://doi.org/10.1002/mdc3.13546
Gubanova EI, Starovatova PA. A prospective, comparative, evaluator-blind clinical study investigating efficacy and safety of two injection techniques with Radiesse(®) for the correction of skin changes in aging hands. J Cutan Aesthet Surg. 2015;8(3):147–152.
https://doi.org/10.4103/0974-2077.167271 DOI: https://doi.org/10.4103/0974-2077.167271
Calomeni M, Bravo B, Schelke LW, et al. Precision of soft-tissue filler injections: an ultrasound-based verification study. Aesthet Surg J. 2023;43(3):353–361.
https://doi.org/10.1093/asj/sjac272 DOI: https://doi.org/10.1093/asj/sjac272
Khosravani N, Weber L, Patel R, Patel A. The 5-step filler hand rejuvenation: filling with hyaluronic acid. Plast Reconstr Surg Glob Open. 2019;7(1):e2073.
https://doi.org/10.1097/GOX.0000000000002073 DOI: https://doi.org/10.1097/GOX.0000000000002073
Park JA, Lee SH, Hwang SJ, Koh KS, Song WC. Anatomic, histologic, and ultrasound analyses of the dorsum of the hand for volumetric rejuvenation. J Plast Reconstr Aesthet Surg. 2021;74(7):1615–1620.
https://doi.org/10.1016/j.bjps.2020.11.017 DOI: https://doi.org/10.1016/j.bjps.2020.11.017
Lacarrubba F, Tedeschi A, Nardone B, Micali G. Mesotherapy for skin rejuvenation: assessment of the subepidermal low-echogenic band by ultrasound evaluation with cross-sectional B-mode scanning. Dermatol Ther. 2008;21(Suppl 3):S1–S5.
https://doi.org/10.1111/j.1529-8019.2008.00234.x DOI: https://doi.org/10.1111/j.1529-8019.2008.00234.x
Tedeschi A, Lacarrubba F, Micali G. Mesotherapy with an intradermal hyaluronic acid formulation for skin rejuvenation: an intrapatient, placebo-controlled, long-term trial using high-frequency ultrasound. Aesthetic Plast Surg. 2015;39(1):129–133.
https://doi.org/10.1007/s00266-014-0432-1 DOI: https://doi.org/10.1007/s00266-014-0432-1
Bertucci V, Solish N, Wong M, Howell M. Evaluation of the merz hand grading scale after calcium hydroxylapatite hand treatment. Dermatol Surg. 2015;41(Suppl 1):S389–S396.
https://doi.org/10.1097/DSS.0000000000000546 DOI: https://doi.org/10.1097/DSS.0000000000000546
Cohen JL, Carruthers A, Jones DH, et al. A randomized, blinded study to validate the merz hand grading scale for use in live assessments. Dermatol Surg. 2015;41(Suppl 1):S384–S388.
https://doi.org/10.1097/DSS.0000000000000553 DOI: https://doi.org/10.1097/DSS.0000000000000553
Lee JH, Choi YS, Park ES, et al. A novel photonumeric hand grading scale for hand rejuvenation. Arch Plast Surg. 2019;46(4):359–364.
https://doi.org/10.5999/aps.2019.00521 DOI: https://doi.org/10.5999/aps.2019.00521
Almadori A, Speiser S, Ashby I, et al. Portable three-dimensional imaging to monitor small volume enhancement in face, vulva, and hand: a comparative study. J Plast Reconstr Aesthet Surg. 2022;75(9):3574–3585.
https://doi.org/10.1016/j.bjps.2022.04.042 DOI: https://doi.org/10.1016/j.bjps.2022.04.042
Cuzalina A, Guerrero AV. Complications in fat grafting. Atlas Oral Maxillofac Surg Clin North Am. 2018;26(1):77–80.
https://doi.org/10.1016/j.cxom.2017.11.003 DOI: https://doi.org/10.1016/j.cxom.2017.11.003
Swift A, Green JB, Hernandez CA, et al. Tips and tricks for facial toxin injections with illustrated anatomy. Plast Reconstr Surg. 2022;149(2):303e–312e.
https://doi.org/10.1097/PRS.0000000000008708 DOI: https://doi.org/10.1097/PRS.0000000000008708
Hong SO. Cosmetic treatment using botulinum toxin in the oral and maxillofacial area: a narrative review of esthetic techniques. Toxins (Basel). 2023;15(2):82.
https://doi.org/10.3390/toxins15020082 DOI: https://doi.org/10.3390/toxins15020082
Zargaran D, Zoller F, Zargaran A, et al. Complications of cosmetic botulinum toxin A injections to the upper face: a systematic review and meta-analysis. Aesthet Surg J. 2022;42(5):NP327–NP336.
https://doi.org/10.1093/asj/sjac036 DOI: https://doi.org/10.1093/asj/sjac036
Senet P, Maillard H, Diot E, et al. Efficacy and safety of botulinum toxin in adults with Raynaud’s phenomenon secondary to systemic sclerosis: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheumatol. 2023;75(3):459–467.
https://doi.org/10.1002/art.42342 DOI: https://doi.org/10.1002/art.42342
Glaser DA, Galperin TA. Botulinum toxin for hyperhidrosis of areas other than the axillae and palms/soles. Dermatol Clin. 2014;32(4):517–525.
https://doi.org/10.1016/j.det.2014.06.001 DOI: https://doi.org/10.1016/j.det.2014.06.001
Sussman J. Musician’s dystonia. Pract Neurol. 2015;15(4):317–322.
https://doi.org/10.1136/practneurol-2015-001148 DOI: https://doi.org/10.1136/practneurol-2015-001148
Goldman JG. Writer’s cramp. Toxicon. 2015;107(Pt A):98–104.
https://doi.org/10.1016/j.toxicon.2015.09.024 DOI: https://doi.org/10.1016/j.toxicon.2015.09.024
Newsome HA, Chi JJ. Mastering midface injections. Clin Plast Surg. 2023;50(3):437–446.
https://doi.org/10.1016/j.cps.2022.12.008 DOI: https://doi.org/10.1016/j.cps.2022.12.008
Buzalaf M, Levy FM. Autologous platelet concentrates for facial rejuvenation. J Appl Oral Sci. 2022;30:e20220020.
https://doi.org/10.1590/1678-7757-2022-0020 DOI: https://doi.org/10.1590/1678-7757-2022-0020
Li G, Wang H. Novel applications of concentrated growth factors in facial rejuvenation and plastic surgery. Facial Plast Surg. 2024;40(1):112–119.
https://doi.org/10.1055/a-1987-3459 DOI: https://doi.org/10.1055/a-1987-3459
Crowley JS, Liu A, Dobke M. Regenerative and stem cell-based techniques for facial rejuvenation. Exp Biol Med (Maywood). 2021;246(16):1829–1837.
https://doi.org/10.1177/15353702211020701 DOI: https://doi.org/10.1177/15353702211020701
Breithaupt A, Fitzgerald R. Collagen stimulators: poly-L-lactic acid and calcium hydroxyl apatite. Facial Plast Surg Clin North Am. 2015;23(4):459–469.
https://doi.org/10.1016/j.fsc.2015.07.007 DOI: https://doi.org/10.1016/j.fsc.2015.07.007
de Melo F, Nicolau P, Piovano L, et al. Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé(®)). Clin Cosmet Investig Dermatol. 2017;10:431–440.
https://doi.org/10.2147/CCID.S145195 DOI: https://doi.org/10.2147/CCID.S145195
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