Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014

Authors

  • Kathrine Kronberg Jakobsen Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Vibe Lindeblad Wingstrand Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Jakob Schmidt Jensen Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Christian Grønhøj Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • David Hebbelstrup Jensen Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Kirstine Karnov Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Tina Klitmøller Agander Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Lena Specht Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Christian von Buchwald Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

DOI:

https://doi.org/10.1080/0284186X.2019.1657585

Abstract

Objectives: To evaluate changes in incidence and survival of patients diagnosed with hypopharyngeal cancer (HPC) in Denmark in the period 1980–2014.

Methods: All patients registered with HPC in the Danish Cancer Registry (DCR) in the period 1980–2014 were included. Age-adjusted incidence rates (AAIRs), average annual percentage change in incidence, and overall survival were calculated.

Results: Two thousand and nine patients were included (79.7% men). The overall AAIR increased significantly from 0.3 per 100,000 to 1.1 per 100,000 during the study period, corresponding to an increase of 4.1% per year. The most frequent histology was squamous cell carcinoma (SCC) comprising 90.3%. The overall five-year survival increased with 13.5 percentage points from 13.4% in the period 1980–1985 to 26.9% in the period 2010–2014. Women demonstrated better survival compared to men with a hazard ratio of 0.83, and patients with SCC had better survival compared to the remaining histology groups.

Conclusions: This nation-wide study, covering nearly four decades, showed a significant increase in incidence and survival of HPC in Denmark.

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Published

2019-11-02

How to Cite

Kronberg Jakobsen, K., Lindeblad Wingstrand, V., Schmidt Jensen, J., Grønhøj, C., Hebbelstrup Jensen, D., Karnov, K., … von Buchwald, C. (2019). Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014. Acta Oncologica, 58(11), 1570–1576. https://doi.org/10.1080/0284186X.2019.1657585

Issue

Vol. 58 No. 11 (2019): Acta Oncologica

Section

Articles