AbobotulinumtoxinA injections in shoulder muscles to improve adult upper limb spasticity: Results from a phase 4 real-world study and a phase 3 open-label trial

Authors

  • Thierry Lejeune
  • Svetlana Khatkova
  • Lynne Turner-Stokes
  • Philippe Picaut
  • Pascal Maisonobe
  • Jovita Balcaitiene
  • François Constant Boyer

DOI:

https://doi.org/10.2340/16501977-2695

Keywords:

botulinum toxins, type A, abobotulinumtoxinA, muscle spasticity, shoulder joint, shoulder pain, observational study, clinical trials, phase III

Abstract

Botulinum toxins, such as abobotulinumtoxinA, are used to treat spasticity (muscle overactivity) in arm muscles. Spasticity in shoulder muscles occurs in many patients following a stroke. Shoulder spasticity can be painful and limit limb movement. This paper compares the results from patients who did and those who did not receive abobotulinumtoxinA injections in shoulder muscles (among other arm muscles) in 2 studies. In both studies, the results showed that more patients receiving treatment in shoulder muscles chose pain as a key goal for treatment and had reduced pain following treatment compared with patients not treated in the shoulder. In addition, patients receiving shoulder injections showed further improvement in arm movement compared with those not receiving shoulder injections. Overall, these results suggest that abobotulinumtoxinA treatment in shoulder muscles may improve outcomes for patients with arm spasticity involving the shoulder.

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Published

2020-06-01

How to Cite

Lejeune, T., Khatkova, S., Turner-Stokes, L., Picaut, P., Maisonobe, P., Balcaitiene, J., & Constant Boyer, F. (2020). AbobotulinumtoxinA injections in shoulder muscles to improve adult upper limb spasticity: Results from a phase 4 real-world study and a phase 3 open-label trial. Journal of Rehabilitation Medicine, 52(6), 1–9. https://doi.org/10.2340/16501977-2695

Issue

Vol. 52 No. 6 (2020)

Section

Original Report

License

All digitalized JRM contents is available freely online. The Foundation for Rehabilitation Medicine owns the copyright for all material published until volume 40 (2008), as from volume 41 (2009) authors retain copyright to their work and as from volume 49 (2017) the journal has been published Open Access, under CC-BY-NC licences (unless otherwise specified). The CC-BY-NC licenses allow third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
From 2024, articles are published under the CC-BY licence. This license permits sharing, adapting, and using the material for any purpose, including commercial use, with the condition of providing full attribution to the original publication.

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