Comparison of ultrasound- vs. landmark-guided injections for musculoskeletal pain: an umbrella review

Authors

  • Peng-Chieh Shen Department of Physical Medicine and Rehabilitation, Lo-Hsu Medical Foundation, Inc., Lotung Poh-Ai Hospital, Yilan City, Taiwan
  • Ting-Yu Lin Department of Physical Medicine and Rehabilitation, Lo-Hsu Medical Foundation, Inc., Lotung Poh-Ai Hospital, Yilan City, Taiwan
  • Wei-Ting Wu Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan
  • Levent Özçakar Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey
  • Ke-Vin Chang Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan; Center for Regional Anesthesia and Pain Medicine, Wang-Fang Hospital, Taipei Medical University, Taipei, Taiwan

DOI:

https://doi.org/10.2340/jrm.v56.40769

Keywords:

Ultrasonography, anatomy, intervention, accuracy, symptom

Abstract

Objective: This umbrella review synthesizes systematic reviews and meta-analyses to reach a conclusion concerning the overall effectiveness of ultrasound-guided vs landmark-guided injections for treating musculoskeletal pain.

Design: Umbrella review.

Methods: PubMed, EMBASE, MEDLINE, and Web of Science were searched for relevant systematic reviews and meta-analyses from inception to March 2024. Critical appraisal, data extraction, and synthesis were performed in accordance with the criteria for conducting an umbrella review.

Results: Seventeen articles, comprising 4 systematic reviews and 13 meta-analyses, were included. Using the AMSTAR2 instrument for quality assessment, 3 articles were rated as high quality, 1 as moderate, 7 as low, and 6 as critically low. Generally, ultrasound-guided injections were found to be more accurate than landmark-guided injections, particularly in the shoulder joint, though the results for pain relief and functional outcomes varied. Ultrasound guidance was notably effective for injections into the bicipital groove, wrist, hip, and knee – yielding greater accuracy and improved pain management. Both ultrasound-guided and landmark-guided techniques showed low incidence of adverse effects.

Conclusion: This umbrella review offers an in-depth analysis of the comparative effectiveness of ultrasound-guided and landmark-guided injections across a range of musculoskeletal sites/conditions. The findings suggest that ultrasound-guided is a reliable method.

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References

Babatunde OO, Jordan JL, Van der Windt DA, Hill JC, Foster NE, Protheroe J. Effective treatment options for musculoskeletal pain in primary care: systematic overview of cur-rent evidence. PLoS One 2017; 12: e0178621.

https://doi.org/10.1371/journal.pone.0178621 DOI: https://doi.org/10.1371/journal.pone.0178621

Phillips M, Bhandari M, Grant J, Bedi A, Trojian T, Johnson A, et al. A systematic review of current clinical practice guidelines on intra-articular hyaluronic acid, corticosteroid, and platelet-rich plasma injection for knee osteoarthritis: an international perspective. Or-thop J Sports Med 2021; 9: 23259671211030272.

https://doi.org/10.1177/23259671211030272 DOI: https://doi.org/10.1177/23259671211030272

Chang KV, Hsiao MY, Chen WS, Wang TG, Chien KL. Effectiveness of intra-articular hyalu-ronic acid for ankle osteoarthritis treatment: a systematic review and meta-analysis. Arch Phys Med Rehabil 2013; 94: 951-960.

https://doi.org/10.1016/j.apmr.2012.10.030 DOI: https://doi.org/10.1016/j.apmr.2012.10.030

Chang KV, Hung CY, Aliwarga F, Wang TG, Han DS, Chen WS. Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis. Arch Phys Med Rehabil 2014; 95: 562-575.

https://doi.org/10.1016/j.apmr.2013.11.006 DOI: https://doi.org/10.1016/j.apmr.2013.11.006

Hall MM. The accuracy and efficacy of palpation versus image-guided peripheral injec-tions in sports medicine. Curr Sports Med Rep 2013; 12: 296-303.

https://doi.org/10.1097/01.CSMR.0000434103.32478.36 DOI: https://doi.org/10.1097/01.CSMR.0000434103.32478.36

Bansal A, Goyal A, Gamanagatti S, Srivastava DN, Manhas V. Current updates in image-guided musculoskeletal interventions. J Clin Orthop Trauma 2021; 22: 101601.

https://doi.org/10.1016/j.jcot.2021.101601 DOI: https://doi.org/10.1016/j.jcot.2021.101601

Florkow MC, Willemsen K, Mascarenhas VV, Oei EHG, van Stralen M, Seevinck PR. Magnet-ic resonance imaging versus computed tomography for three-dimensional bone imaging of musculoskeletal pathologies: a review. J Magn Reson Imaging 2022; 56: 11-34.

https://doi.org/10.1002/jmri.28067 DOI: https://doi.org/10.1002/jmri.28067

Beigi P, Salcudean SE, Ng GC, Rohling R. Enhancement of needle visualization and locali-zation in ultrasound. Int J Comput Assist Radiol Surg 2021; 16: 169-178.

https://doi.org/10.1007/s11548-020-02227-7 DOI: https://doi.org/10.1007/s11548-020-02227-7

Klibanov AL, Hossack JA. Ultrasound in radiology: from anatomic, functional, molecular imaging to drug delivery and image-guided therapy. Invest Radiol 2015; 50: 657-670.

https://doi.org/10.1097/RLI.0000000000000188 DOI: https://doi.org/10.1097/RLI.0000000000000188

Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical ap-praisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ 2017; 358: j4008.

https://doi.org/10.1136/bmj.j4008 DOI: https://doi.org/10.1136/bmj.j4008

Soh E, Li W, Ong KO, Chen W, Bautista D. Image-guided versus blind corticosteroid injec-tions in adults with shoulder pain: a systematic review. BMC Musculoskelet Disord 2011; 12: 137.

https://doi.org/10.1186/1471-2474-12-137 DOI: https://doi.org/10.1186/1471-2474-12-137

Sage W, Pickup L, Smith TO, Denton ER, Toms AP. The clinical and functional outcomes of ultrasound-guided vs landmark-guided injections for adults with shoulder pathology: a systematic review and meta-analysis. Rheumatology (Oxford) 2013; 52: 743-751.

https://doi.org/10.1093/rheumatology/kes302 DOI: https://doi.org/10.1093/rheumatology/kes302

Aly AR, Rajasekaran S, Ashworth N. Ultrasound-guided shoulder girdle injections are more accurate and more effective than landmark-guided injections: a systematic review and meta-analysis. Br J Sports Med 2015; 49: 1042-1049.

https://doi.org/10.1136/bjsports-2014-093573 DOI: https://doi.org/10.1136/bjsports-2014-093573

Huang Z, Du S, Qi Y, Chen G, Yan W. Effectiveness of ultrasound guidance on intraarticu-lar and periarticular joint injections: systematic review and meta-analysis of randomized trials. Am J Phys Med Rehabil 2015; 94: 775-783.

https://doi.org/10.1097/PHM.0000000000000260 DOI: https://doi.org/10.1097/PHM.0000000000000260

Wu T, Song HX, Dong Y, Li JH. Ultrasound-guided versus blind subacromial-subdeltoid bursa injection in adults with shoulder pain: a systematic review and meta-analysis. Semin Arthritis Rheum 2015; 45: 374-378.

https://doi.org/10.1016/j.semarthrit.2015.05.011 DOI: https://doi.org/10.1016/j.semarthrit.2015.05.011

Hoeber S, Aly AR, Ashworth N, Rajasekaran S. Ultrasound-guided hip joint injections are more accurate than landmark-guided injections: a systematic review and meta-analysis. Br J Sports Med 2016; 50: 392-396.

https://doi.org/10.1136/bjsports-2014-094570 DOI: https://doi.org/10.1136/bjsports-2014-094570

Wu T, Dong Y, Song H, Fu Y, Li JH. Ultrasound-guided versus landmark in knee arthrocen-tesis: a systematic review. Semin Arthritis Rheum 2016; 45: 627-632.

https://doi.org/10.1016/j.semarthrit.2015.10.011 DOI: https://doi.org/10.1016/j.semarthrit.2015.10.011

Simoni P, Grumolato M, Malaise O, Preziosi M, Pasleau F, de Lemos Esteves F. Are blind injections of gleno-humeral joint (GHJ) really less accurate imaging-guided injections? A narrative systematic review considering multiple anatomical approaches. Radiol Med 2017; 122: 656-675.

https://doi.org/10.1007/s11547-017-0772-4 DOI: https://doi.org/10.1007/s11547-017-0772-4

Ayekoloye CI, Nwangwu O. Ultrasound-guided versus anatomic landmark-guided steroid injection of the subacromial bursa in the management of subacromial impingement: a systematic review of randomised control studies. Indian J Orthop 2020; 54: 10-19.

https://doi.org/10.1007/s43465-020-00148-w DOI: https://doi.org/10.1007/s43465-020-00148-w

Fang WH, Chen XT, Vangsness CT, Jr. Ultrasound-guided knee injections are more accu-rate than blind injections: a systematic review of randomized controlled trials. Arthrosc Sports Med Rehabil 2021; 3: e1177-e1187.

https://doi.org/10.1016/j.asmr.2021.01.028 DOI: https://doi.org/10.1016/j.asmr.2021.01.028

Adamson NJ, Tsuro M, Adams N. Ultrasound-guided versus landmark-guided subacro-mial corticosteroid injections for rotator cuff related shoulder pain: a systematic review of randomised controlled trials. Musculoskeletal Care 2022; 20: 784-795.

https://doi.org/10.1002/msc.1643 DOI: https://doi.org/10.1002/msc.1643

Deng X, Zhu S, Li D, Luo Y, Zhang X, Tan Y, et al. Effectiveness of ultrasound-guided versus anatomic landmark-guided corticosteroid injection on pain, physical function, and safe-ty in patients with subacromial impingement syndrome: a systematic review and meta-analysis. Am J Phys Med Rehabil 2022; 101: 1087-1098.

https://doi.org/10.1097/PHM.0000000000001940 DOI: https://doi.org/10.1097/PHM.0000000000001940

Fan D, Liu X, Ma J, Zhang S, Sun J, Li Y, et al. Ultrasound guidance is not superior in sub-acromial bursa and intraarticular injections but superior in bicipital groove: a meta-analysis of randomized controlled trials. Arthroscopy 2022; 38: 1642-1657.

https://doi.org/10.1016/j.arthro.2021.12.013 DOI: https://doi.org/10.1016/j.arthro.2021.12.013

ElMeligie MM, Allam NM, Yehia RM, Ashour AA. Systematic review and meta-analysis on the effectiveness of ultrasound-guided versus landmark corticosteroid injection in the treatment of shoulder pain: an update. J Ultrasound 2023; 26: 593-604.

https://doi.org/10.1007/s40477-022-00684-1 DOI: https://doi.org/10.1007/s40477-022-00684-1

He KS, He KS, Cheah A, Al-Halabi B, Danino MA, Efanov JI. Unblinding de Quervain: a sys-tematic review of ultrasound-guided injection of corticosteroids for treatment of stenosing tenosynovitis of the 1st extensor compartment. J Med Radiat Sci 2023; 70: 319-326.

https://doi.org/10.1002/jmrs.681 DOI: https://doi.org/10.1002/jmrs.681

Bloom JE, Rischin A, Johnston RV, Buchbinder R. Image-guided versus blind glucocorti-coid injection for shoulder pain. Cochrane Database of Systematic Reviews 2012; 10.1002/14651858.CD009147.pub2.

https://doi.org/10.1002/14651858.CD009147.pub2 DOI: https://doi.org/10.1002/14651858.CD009147.pub2

Zadro J, Rischin A, Johnston RV, Buchbinder R. Image-guided glucocorticoid injection versus injection without image guidance for shoulder pain. Cochrane Database Syst Rev 2021; 8: CD009147.

https://doi.org/10.1002/14651858.CD009147.pub3 DOI: https://doi.org/10.1002/14651858.CD009147.pub3

Sekizkardeş M, Aydin G, Özçakar L. Ultrasound-guided shoulder injection or ultrasound guides the shoulder injection?: standard versus state-of-the-art. Am J Phys Med Rehabil 2018; 97: e46.

https://doi.org/10.1097/PHM.0000000000000900 DOI: https://doi.org/10.1097/PHM.0000000000000900

Hsieh LF, Hsu WC, Lin YJ, Wu SH, Chang KC, Chang HL. Is ultrasound-guided injection more effective in chronic subacromial bursitis? Med Sci Sports Exerc 2013; 45: 2205-2213.

https://doi.org/10.1249/MSS.0b013e31829b183c DOI: https://doi.org/10.1249/MSS.0b013e31829b183c

Haghighat S, Taheri P, Banimehdi M, Taghavi A. Effectiveness of blind & ultrasound guided corticosteroid injection in impingement syndrome. Glob J Health Sci 2015; 8: 179-184.

https://doi.org/10.5539/gjhs.v8n7p179 DOI: https://doi.org/10.5539/gjhs.v8n7p179

Azadvari M, Emami-Razavi SZ, Torfi F, Nazar NSB, Malekirad AA. Ultrasound-guided versus blind subacromial bursa corticosteroid injection for paraplegic spinal cord injury pa-tients with rotator cuff tendinopathy: a randomized, single-blind clinical trial. Int J Neu-rosci 2021; 131: 445-452.

https://doi.org/10.1080/00207454.2020.1748620 DOI: https://doi.org/10.1080/00207454.2020.1748620

Ucuncu F, Capkin E, Karkucak M, Ozden G, Cakirbay H, Tosun M, et al. A comparison of the effectiveness of landmark-guided injections and ultrasonography guided injections for shoulder pain. Clin J Pain 2009; 25: 786-789.

https://doi.org/10.1097/AJP.0b013e3181acb0e4 DOI: https://doi.org/10.1097/AJP.0b013e3181acb0e4

Dogu B, Yucel SD, Sag SY, Bankaoglu M, Kuran B. Blind or ultrasound-guided corticoster-oid injections and short-term response in subacromial impingement syndrome: a ran-domized, double-blind, prospective study. Am J Phys Med Rehabil 2012; 91: 658-665.

https://doi.org/10.1097/PHM.0b013e318255978a DOI: https://doi.org/10.1097/PHM.0b013e318255978a

Cole BF, Peters KS, Hackett L, Murrell GA. Ultrasound-guided versus blind subacromial corticosteroid injections for subacromial impingement syndrome: a randomized, dou-ble-blind clinical trial. Am J Sports Med 2016; 44: 702-707.

https://doi.org/10.1177/0363546515618653 DOI: https://doi.org/10.1177/0363546515618653

Ekeberg OM, Bautz-Holter E, Tveitå EK, Juel NG, Kvalheim S, Brox JI. Subacromial ultra-sound guided or systemic steroid injection for rotator cuff disease: randomised double blind study. BMJ 2009; 338: a3112.

https://doi.org/10.1136/bmj.a3112 DOI: https://doi.org/10.1136/bmj.a3112

Akbari N, Ozen S, Şenlikçi HB, Haberal M, Çetin N. Ultrasound-guided versus blind subacromial corticosteroid and local anesthetic injection in the treatment of subacro-mial impingement syndrome: a randomized study of efficacy. Jt Dis Relat Surg 2020; 31: 115-122.

https://doi.org/10.5606/ehc.2020.71056 DOI: https://doi.org/10.5606/ehc.2020.71056

Raeissadat SA, Rayegani SM, Langroudi TF, Khoiniha M. Comparing the accuracy and effi-cacy of ultrasound-guided versus blind injections of steroid in the glenohumeral joint in patients with shoulder adhesive capsulitis. Clin Rheumatol 2017; 36: 933-940.

https://doi.org/10.1007/s10067-016-3393-8 DOI: https://doi.org/10.1007/s10067-016-3393-8

Panditaratne N, Wilkinson C, Groves C, Chandramohan M. Subacromial impingement syndrome: a prospective comparison of ultrasound-guided versus unguided injection techniques. Ultrasound 2010; 18: 176-181.

https://doi.org/10.1258/ult.2010.010022 DOI: https://doi.org/10.1258/ult.2010.010022

Satpute K, Reid S, Mitchell T, Mackay G, Hall T. Efficacy of mobilization with movement (MWM) for shoulder conditions: a systematic review and meta-analysis. J Man Manip Ther 2022; 30: 13-32.

https://doi.org/10.1080/10669817.2021.1955181 DOI: https://doi.org/10.1080/10669817.2021.1955181

Simovitch RW, Elwell J, Colasanti CA, Hao KA, Friedman RJ, Flurin PH, et al. Stratification of the minimal clinically important difference, substantial clinical benefit, and patient acceptable symptomatic state after total shoulder arthroplasty by implant type, preope-rative diagnosis, and sex. J Shoulder Elbow Surg 2024; 10.1016/j.jse.2024.01.040.

https://doi.org/10.1016/j.jse.2024.01.040 DOI: https://doi.org/10.1016/j.jse.2024.01.040

Hashiuchi T, Sakurai G, Morimoto M, Komei T, Takakura Y, Tanaka Y. Accuracy of the biceps tendon sheath injection: ultrasound-guided or unguided injection? A randomized con-trolled trial. J Shoulder Elbow Surg 2011; 20: 1069-1073.

https://doi.org/10.1016/j.jse.2011.04.004 DOI: https://doi.org/10.1016/j.jse.2011.04.004

Lee ZH, Stranix JT, Anzai L, Sharma S. Surgical anatomy of the first extensor compartment: a systematic review and comparison of normal cadavers vs De Quervain syndrome pati-ents. J Plast Reconstr Aesthet Surg 2017; 70: 127-131.

https://doi.org/10.1016/j.bjps.2016.08.020 DOI: https://doi.org/10.1016/j.bjps.2016.08.020

Chang KV, Hung CY, Özçakar L. Ultrasound imaging for precise diagnosis and injection of isolated extensor pollicis brevis tenosynovitis: it is not always a simple de Quervain dise-ase. Am J Phys Med Rehabil 2015; 94: 255.

https://doi.org/10.1097/PHM.0000000000000247 DOI: https://doi.org/10.1097/PHM.0000000000000247

Kurup H, Ward P. Do we need radiological guidance for hip joint injections? Acta Orthop Belg 2010; 76: 205-207.

Additional Files

Published

2024-08-26

How to Cite

Shen, P.-C., Lin, T.-Y., Wu, W.-T., Özçakar , L., & Chang, K.-V. (2024). Comparison of ultrasound- vs. landmark-guided injections for musculoskeletal pain: an umbrella review. Journal of Rehabilitation Medicine, 56, jrm40679. https://doi.org/10.2340/jrm.v56.40769