Impact of multidisciplinary rehabilitation on functioning and quality of life in stroke survivors: a longitudinal retrospective analysis
DOI:
https://doi.org/10.2340/jrm.v58.42921Keywords:
stroke, rehabilitation, health-related quality of life, EQ-5D, WHODAS 2.0, mRS, multidisciplinary careAbstract
Objective: This study investigates the impact of different rehabilitation approaches on functional recovery and health-related quality of life (HRQoL) in stroke patients.
Design: A longitudinal retrospective observational study.
Subjects: The study included all 538 consecutive stroke patients treated in Satakunta County, Finland, between January 2021 and January 2022.
Methods: Functional recovery was assessed using the modified Rankin Scale (mRS), WHODAS 2.0, and HRQoL using the EQ-5D. Outcomes were evaluated at 1, 3, 6, and 12 months. Patients were categorized into 3 groups: no rehabilitation, primary care (PC) rehabilitation, and multidisciplinary (MD) rehabilitation. Longitudinal changes in mRS, WHODAS, and EQ-5D were further assessed at a 3-year follow-up.
Results: MD rehabilitation resulted in significantly greater improvements in HRQoL and functional recovery compared with PC rehabilitation and no rehabilitation. Female patients reported lower HRQoL and poorer functioning than males; however, rates of improvement were similar between the sexes. Dependency (mRS > 2) was associated with lower HRQoL, although changes over the 1-year follow-up were comparable between dependent and independent patients. Depression emerged as the strongest predictor of HRQoL improvements. Substantial correlations were observed among mRS, EQ-5D, and WHODAS 2.0 scores, with the strength of these correlations increasing over time. At the 3-year follow-up, stroke survivors continued to exhibit decreasing HRQoL and functional status.
Conclusions: Multidisciplinary rehabilitation substantially enhances functional recovery and HRQoL during the first year after stroke compared with primary care or no rehabilitation. Although women and patients with greater dependency report lower HRQoL, their rates of improvement are similar to those of other groups. Depression is a key determinant of HRQoL gains, underscoring the importance of integrating mental health support into rehabilitation pathways. The persistently low HRQoL observed 3 years post-stroke highlights the long-term burden of stroke and the need for sustained, comprehensive follow-up and rehabilitation strategies to address ongoing functional limitations.
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References
Langhorne P, Coupar F, Pollock A. Motor recovery after stroke: a systematic review. Lancet Neurol 2009; 8: 741–754.
https://doi.org/10.1016/S1474-4422(09)70150-4 DOI: https://doi.org/10.1016/S1474-4422(09)70150-4
Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol 2009; 8: 1006–1018.
https://doi.org/10.1016/S1474-4422(09)70236-4 DOI: https://doi.org/10.1016/S1474-4422(09)70236-4
Sexton E, McLoughlin A, Williams DJ, Merriman NA, Donnelly N, Rohde D, et al. Systematic review and meta-analysis of the prevalence of cognitive impairment no dementia in the first year post-stroke. Eur Stroke J 2019; 4: 160–171.
https://doi.org/10.1177/2396987318825484 DOI: https://doi.org/10.1177/2396987318825484
Flowers HL, Skoretz SA, Silver FL, Rochon E, Fang J, Flamand-Roze C, et al. Poststroke aphasia frequency, recovery, and outcomes: a systematic review and meta-analysis. Arch Phys Med Rehabil 2016; 97: 2188–2201.
https://doi.org/10.1016/j.apmr.2016.03.006 DOI: https://doi.org/10.1016/j.apmr.2016.03.006
Mitchell AJ, Sheth B, Gill J, Yadegarfar M, Stubbs B, Yadegarfar M, et al. Prevalence and predictors of post-stroke mood disorders: a meta-analysis and meta-regression. Gen Hosp Psychiatry 2017; 47: 48–60.
https://doi.org/10.1016/j.genhosppsych.2017.04.001 DOI: https://doi.org/10.1016/j.genhosppsych.2017.04.001
Souza AC, Rocha MO, Teixeira AL, Dias Junior JO, de Sousa LA, Nunes MCP. Depressive symptoms and disability in chagasic stroke patients: impact on functionality and quality of life. J Neurol Sci 2013; 324: 34–37.
https://doi.org/10.1016/j.jns.2012.09.022 DOI: https://doi.org/10.1016/j.jns.2012.09.022
Hüwel J, Weisner B, Kemmer H, Heyder J. Depressive Verstimmung im Akutstadium nach erstmaligem ischämischen Hirninfarkt [Depressed mood in the acute phase of first ischaemic cerebral infarct]. Nervenarzt 1998; 69: 330–334.
https://doi.org/10.1007/s001150050278 DOI: https://doi.org/10.1007/s001150050278
Ibrahimagic OC, Smajlovic D, Kunic S, Sinanovic O. Post-stroke depression. Mater Sociomed 2019; 31: 31–34. DOI: https://doi.org/10.5455/msm.2019.31.31-34
Kim JS, Choi-Kwon S, Kwon SU, Lee HJ, Park KA, Seo YS. Factors affecting the quality of life after ischemic stroke: young versus old patients. J Clin Neurol 2005; 1: 59–68.
https://doi.org/10.3988/jcn.2005.1.1.59 DOI: https://doi.org/10.3988/jcn.2005.1.1.59
Bindawas SM, Vennu V, Moftah E. Improved functions and reduced length of stay after inpatient rehabilitation programs in older adults with stroke: a systematic review and meta-analysis of randomized controlled trials. NeuroRehabilitation 2017; 40: 369–390.
https://doi.org/10.3233/NRE-161425 DOI: https://doi.org/10.3233/NRE-161425
Kuivanen S, Mikkelsson M. Outpatient rehabilitation after stroke in the Päijät-Häme Joint Authority for Health and Social Care. Suom Lääkäril 2019; 74: 2226–2230.
Ristmägi A, Tikka V, Lampinen-Laine V, Heikkilä H. Rehabilitation of stroke patients in Satakunta district: 1-year follow-up. Suom Lääkäril 2022; 77: e31880.
Mittmann N, Trakas K, Risebrough N, Liu BA. Utility scores for chronic conditions in a community-dwelling population. Pharmacoeconomics 1999; 15: 369–376.
https://doi.org/10.2165/00019053-199915040-00004 DOI: https://doi.org/10.2165/00019053-199915040-00004
Sturm JW, Donnan GA, Dewey HM, Macdonell RAL, Gilligan AK, Srikanth V, et al. Quality of life after stroke: the North East Melbourne Stroke Incidence Study (NEMESIS). Stroke 2004; 35: 2340–2345.
https://doi.org/10.1161/01.STR.0000141977.18520.3b DOI: https://doi.org/10.1161/01.STR.0000141977.18520.3b
Paul SL, Sturm JW, Dewey HM, Donnan GA, Macdonell RAL. Long-term outcome in the North East Melbourne Stroke Incidence Study: predictors of quality of life at 5 years after stroke. Stroke 2005; 36: 2082–2086.
https://doi.org/10.1161/01.STR.0000183621.32045.31 DOI: https://doi.org/10.1161/01.STR.0000183621.32045.31
Almborg AH, Ulander K, Thulin A, Berg S. Discharged after stroke – important factors for health-related quality of life. J Clin Nurs 2010; 19: 2196–206.
https://doi.org/10.1111/j.1365-2702.2010.03251.x DOI: https://doi.org/10.1111/j.1365-2702.2010.03251.x
Darlington AS, Dippel DWJ, Ribbers GM, van Balen R, Passchier J, Busschbach JJV. A prospective study on coping strategies and quality of life in patients after stroke, assessing prognostic relationships and estimates of cost-effectiveness. J Rehabil Med 2009; 41: 237–241.
https://doi.org/10.2340/16501977-0313 DOI: https://doi.org/10.2340/16501977-0313
Visser MM, Heijenbrok-Kal MH, Spijker AV, Oostra KM, Busschbach JJV, Ribbers GM. Coping, problem solving, depression, and health-related quality of life in outpatient stroke rehabilitation. Arch Phys Med Rehabil 2015; 96: 1492–1498.
https://doi.org/10.1016/j.apmr.2015.04.007 DOI: https://doi.org/10.1016/j.apmr.2015.04.007
Üstün TB, Kostanjsek N, Chatterji S, Rehm J, editors. Measuring health and disability: manual for WHO Disability Assessment Schedule (WHODAS 2.0). Geneva: WHO; 2010.
Küçükdeveci AA, Kutlay Ş, Yıldızlar D, Öztuna D, Elhan AH, Tennant A. The reliability and validity of the World Health Organization Disability Assessment Schedule (WHODAS-II) in stroke. Disabil Rehabil 2013; 35: 214–220.
https://doi.org/10.3109/09638288.2012.690817 DOI: https://doi.org/10.3109/09638288.2012.690817
EuroQol – a new facility for the measurement of health-related quality of life [WHODAS 2.0: Terveyden ja toimintarajoitteiden arvioinnin käsikirja]. Jyväskylä: Jyväskylän ammattikorkeakoulu; 2014.
EuroQol Group. EuroQol – a new facility for the measurement of health-related quality of life. Health Policy 1990; 16: 199–208.
https://doi.org/10.1016/0168-8510(90)90421-9 DOI: https://doi.org/10.1016/0168-8510(90)90421-9
van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJA, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1988; 19: 604–607.
https://doi.org/10.1161/01.str.19.5.604 DOI: https://doi.org/10.1161/01.STR.19.5.604
Broderick JP, Adeoye O, Elm J. Evolution of the Modified Rankin Scale and its use in future stroke trials. Stroke 2017; 48: 2007–2012.
https://doi.org/10.1161/STROKEAHA.117.017866 DOI: https://doi.org/10.1161/STROKEAHA.117.017866
Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983; 67: 361–370.
https://doi.org/10.1111/j.1600-0447.1983.tb09716.x DOI: https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
Sintonen H. The 15D instrument of health-related quality of life: properties and applications. Ann Med 2001; 33: 328–336.
https://doi.org/10.3109/07853890109002086 DOI: https://doi.org/10.3109/07853890109002086
Tarvonen-Schröder S, Hurme S, Laimi K. The World Health Organization Disability Assessment Schedule (WHODAS 2.0) and the WHO Minimal Generic Set of Domains of Functioning and Health versus conventional instruments in subacute stroke. J Rehabil Med 2019; 51: 675–682.
https://doi.org/10.2340/16501977-2583 DOI: https://doi.org/10.2340/16501977-2583
Arowoiya AI, Elloker T, Karachi F, Mlenzana LA, Jacobs-Nzuzi Khuabi LA, Rhoda A. Using the World Health Organization’s Disability Assessment Schedule (2) to assess disability in community-dwelling stroke patients. S Afr J Physiother 2017; 73: 343.
https://doi.org/10.4102/sajp.v73i1.343 DOI: https://doi.org/10.4102/sajp.v73i1.343
Jen HJ, Kao CM, Chang KH, Yen CF, Liao HF, Chi WK et al. Assessment of functioning using the WHODAS 2.0 among people with stroke in Taiwan: a 4-year follow-up study. Ann Phys Rehabil Med 2021; 64: 101442.
https://doi.org/10.1016/j.rehab.2020.09.006 DOI: https://doi.org/10.1016/j.rehab.2020.09.006
Kilkki M, Stolt M, Rannikko S, Pasanen M, Tarvonen-Schröder S. Patient- and proxy-perceptions on functioning after stroke rehabilitation using the 12-item WHODAS 2.0: a longitudinal cohort study. Disabil Rehabil 2024; 46: 783–792.
https://doi.org/10.1080/09638288.2023.2173813 DOI: https://doi.org/10.1080/09638288.2023.2173813
Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Erlbaum; 1988.
Harrison JK, McArthur KS, Quinn TJ. Assessment scales in stroke: clinimetric and clinical considerations. Clin Interv Aging 2013; 8: 201–211.
https://doi.org/10.2147/CIA.S32405 DOI: https://doi.org/10.2147/CIA.S32405
Bath PM, Lees KR, Schellinger PD, Altman H, Bland M, Hogg C, et al. Statistical analysis of primary outcomes in acute stroke trials. Stroke 2012; 43: 1171–1178.
https://doi.org/10.1161/STROKEAHA.111.641456 DOI: https://doi.org/10.1161/STROKEAHA.111.641456
Howard G, Waller JL, Voeks JH, Howard VJ, Jauch EC, Lees KR, et al. A simple, assumption-free, and clinically interpretable approach for analysis of modified Rankin outcomes. Stroke 2012; 43: 664–669.
https://doi.org/10.1161/STROKEAHA.111.632935 DOI: https://doi.org/10.1161/STROKEAHA.111.632935
Saver JL. Optimal end points for acute stroke therapy trials: best ways to measure treatment effects of drugs and devices. Stroke 2011; 42: 2356–2362.
https://doi.org/10.1161/STROKEAHA.111.619122 DOI: https://doi.org/10.1161/STROKEAHA.111.619122
Chaisinanunkul N, Adeoye O, Lewis RJ, Grotta JC, Broderick J, Jovin TG, et al. Adopting a patient-centered approach to primary outcome analysis of Acute Stroke Trials using a utility-weighted modified Rankin Scale. Stroke 2015; 46: 2238–2243.
https://doi.org/10.1161/STROKEAHA.114.008547 DOI: https://doi.org/10.1161/STROKEAHA.114.008547
Kim SK, Kim SH, Jo MW, Lee SI. Estimation of minimally important differences in the EQ-5D and SF-6D indices and their utility in stroke. Health Qual Life Outcomes 2015; 13: 32.
https://doi.org/10.1186/s12955-015-0227-3 DOI: https://doi.org/10.1186/s12955-015-0227-3
Kim ES, Kim JW, Kang HJ, Bae KY, Kim SW, Kim JM, et al. Longitudinal impact of depression on quality of life in stroke patients. Psychiatry Investig 2018; 15: 141–146.
https://doi.org/10.30773/pi.2017.10.11 DOI: https://doi.org/10.30773/pi.2017.10.11
Sadlonova M, Wasser K, Nagel J, Weber-Kruger M, Gröschel S, Uphaus T, et al. Health-related quality of life, anxiety and depression up to 12 months post-stroke: influence of sex, age, stroke severity and atrial fibrillation – a longitudinal subanalysis of the Find-AFRANDOMISED trial. J Psychosom Res 2021; 142: 110353.
https://doi.org/10.1016/j.jpsychores.2020.110353 DOI: https://doi.org/10.1016/j.jpsychores.2020.110353
Pan JH, Song XY, Lee SY, Kwok T. Longitudinal analysis of quality of life for stroke survivors. Stroke 2008; 39: 2795–2802.
https://doi.org/10.1161/STROKEAHA.108.515460 DOI: https://doi.org/10.1161/STROKEAHA.108.515460
Barbosa PM, Ferreira LN, Cruz VT, Silva A, Szrek H. Healthcare, clinical factors and rehabilitation predicting quality of life in first-time stroke patients: a 12-month longitudinal study. J Stroke Cerebrovasc Dis 2022; 31: 106300.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106300 DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106300
Ayerbe L, Ayis S, Wolfe CD, Rudd AG. Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis. Br J Psychiatry 2013; 202: 14–21.
https://doi.org/10.1192/bjp.bp.111.107664 DOI: https://doi.org/10.1192/bjp.bp.111.107664
Paton M, Lane R, Paul E, Linke N, Shehabi Y, Hodgson CL. Correlation of patient-reported outcome measures to performance-based function in critical care survivors: PREDICTABLE. Aust Crit Care 2023; 36: 485–491.
https://doi.org/10.1016/j.aucc.2022.05.006 DOI: https://doi.org/10.1016/j.aucc.2022.05.006
Hartley T, Burger M, Inglis-Jassiem G. Post stroke health-related quality of life, stroke severity and function: a longitudinal cohort study. Afr J Disabil 2022; 11: 947.
https://doi.org/10.4102/ajod.v11i0.947. eCollection 2022 DOI: https://doi.org/10.4102/ajod.v11i0.947
Pucciarelli G, Brugnera A, Greco A, Petrizzo A, Simeone S, Vellone E, et al. Stroke disease-specific quality of life trajectories after rehabilitation discharge and their sociodemographic and clinical associations: a longitudinal, multicentre study. J Adv Nurs 2021; 77: 1856–1866.
https://doi.org/10.1111/jan.14722 DOI: https://doi.org/10.1111/jan.14722
Orman Z, Thrift AG, Olaiya MT, Ung D, Cadilhac DA, Phan T, et al. Quality of life after stroke: a longitudinal analysis of a cluster randomized trial. Qual Life Res 2022; 31: 2445–2455.
https://doi.org/10.1007/s11136-021-03066-y DOI: https://doi.org/10.1007/s11136-021-03066-y
Choi-Kwon S, Choi JM, Kwon S, Kang DW, Kim JS. Factors affecting QOL at 3 years post-stroke. J Clin Neurol 2006; 2: 34–41.
https://doi.org/10.3988/jcn.2006.2.1.34 DOI: https://doi.org/10.3988/jcn.2006.2.1.34
Jonkman EJ, de Weerd AW, Vrijens NL. Quality of life after a first ischemic stroke: long-term developments and correlations with changes in neurological deficit, mood and cognitive impairment. Acta Neurol Scand 1998; 98: 169–175.
https://doi.org/10.1111/j.1600-0404.1998.tb07289.x DOI: https://doi.org/10.1111/j.1600-0404.1998.tb07289.x
Niemi ML, Laaksonen R, Kotila M, Waltimo O. Quality of life 4 years after stroke. Stroke 1989; 19: 1101–1106.
https://doi.org/10.1161/01.str.19.9.1101 DOI: https://doi.org/10.1161/01.STR.19.9.1101
Carod-Artal J, Egido JA, González JL, Varela de Seijas E. Quality of life among stroke survivors evaluated 1 year after stroke: experience of a stroke unit. Stroke 2000; 31: 2995–3000.
https://doi.org/10.1161/01.str.31.12.2995 DOI: https://doi.org/10.1161/01.STR.31.12.2995
Williams LS, Kroenke K, Weinberger M, Harris LE, Biller J. Post-stroke depression affects quality of life (QOL) but not other stroke outcome measures. Stroke 1999; 30: 236–239. DOI: https://doi.org/10.1161/01.STR.30.7.1362
Åström M, Asplund K, Åström T. Psychosocial function and life satisfaction after stroke. Stroke 1992; 23: 527–531.
https://doi.org/10.1161/01.str.23.4.527 DOI: https://doi.org/10.1161/01.STR.23.4.527
King RB. Quality of life after stroke. Stroke 1996; 27: 1467–1472.
https://doi.org/10.1161/01.str.27.9.1467 DOI: https://doi.org/10.1161/01.STR.27.9.1467
Kwa VIH, Limburg M, de Haan RJ. The role of cognitive impairment in the quality of life after ischaemic stroke. J Neurol 1996; 243: 599–604.
https://doi.org/10.1007/BF00900948 DOI: https://doi.org/10.1007/BF00900948
de Haan RJ, Limburg M, van der Meulen JHP, Jacobs HM, Aaronson NK. Quality of life after stroke. Impact of stroke type and lesion location. Stroke 1995; 26: 402–408.
https://doi.org/10.1161/01.str.26.3.402 DOI: https://doi.org/10.1161/01.STR.26.3.402
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