Long-term outcomes following a pulmonary telerehabilitation trial for people with respiratory post-acute sequelae of COVID: a 12-month follow-up study
DOI:
https://doi.org/10.2340/jrm.v58.44828Keywords:
post-acute sequelae of COVID (PASC), respiratory symptoms, Telerehabilitation, cohort studyAbstract
Objective: To determine whether changes in physical and psychological outcomes occurred in the 12 months following completion of a randomized controlled trial comparing a 4-week pulmonary telerehabilitation programme with a control group of usual care in people with respiratory post-acute sequelae of COVID.
Methods: This was a prospective, observational, multi-site, assessor-blinded study. Primary outcome: 1-minute sit-to-stand test. Secondary outcomes: 5-repetition sit-to-stand test; Montreal Cognitive Assessment; COVID-19 Yorkshire Rehabilitation Scale; COPD Assessment Test; 36-Item Short-Form Health Survey; Hospital Anxiety and Depression Scale; Fatigue Severity Scale; and the Kessler Psychological Distress Scale. All outcomes were assessed at baseline and 12 months following randomized controlled trial participation. All participants were analysed as a single group at 12 months, given there were no significant differences in the randomized controlled trial.
Results: Of 50 participants enrolled in the randomized controlled trial, 29 (58%) participated in the 12-month follow-up. Compared with baseline, at the 12-month follow-up there was no statistically significant improvement in the primary outcome of the 1-min sit-to-stand test (1.5 points, CI: –1.3 to 4.2), yet statistically significant differences in the 5-repetition sit-to-stand test (–1.4 seconds CI: –2.7 to –0.1), COPD Assessment Test (–4.1 points CI: –6.8 to –1.4), and some domains of SF-36 and COVID-19 Yorkshire Rehabilitation Scale.
Conclusion: This study demonstrated that people reporting respiratory post-acute sequelae of COVID experienced some recovery at 12 months, despite not improving initially during a 4-week pulmonary telerehabilitation programme or control period.
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Copyright (c) 2026 Jack M. Reeves, Lisa M. Spencer, Ling-Ling Tsai, Andrew J. Baillie, Joshua Bishop, Amanda McAnulty, Yuna Han, Regina Leung, Jennifer A. Alison

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