NASA lean test detects postural orthostatic tachycardia in chronic post-COVID

Authors

  • Mario Siebler Institute of Rehabilitation Research, MediClin, Offenburg, Germany; Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • Andrea Maier Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany
  • Stephan Theiss Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • Sarah Bergé Institute of Rehabilitation Research, MediClin, Offenburg, Germany
  • Anna Bittner Institute of Rehabilitation Research, MediClin, Offenburg, Germany
  • Grit Schiefelbein Institute of Rehabilitation Research, MediClin, Offenburg, Germany
  • Jürgen Wagner Institute of Rehabilitation Research, MediClin, Offenburg, Germany
  • Dominik Raab Chair for Mechanics and Robotics, University of Duisburg-Essen, Duisburg, Germany

DOI:

https://doi.org/10.2340/jrm.v58.45865

Keywords:

autonomic dysregulation, POTS, Post COVID, Long COVID, NASA Lean Test, subtype

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References

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Fedorowski A, Sutton R. Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome. Nat Rev Cardiol 2023; 20: 281–282. DOI: https://doi.org/10.1038/s41569-023-00842-w

Lee C, Greenwood DC, Master H, Balasundaram K, Williams P, Scott JT, et al. Prevalence of orthostatic intolerance in long Covid clinic patients and healthy volunteers: a multicenter study. J Med Virol 2024; 96: e29486. DOI: https://doi.org/10.1002/jmv.29486

Cantrell C, Reid C, Walker CS, Stallkamp Tidd SJ, Zhang R, Wilson R. Post-COVID postural orthostatic tachycardia syndrome (POTS): a new phenomenon. Front Neurol 2024; 15: 1297964. DOI: https://doi.org/10.3389/fneur.2024.1297964

Sheldon RS, Grubb BP, Olshansky B, Shen W-K, Calkins H, Brignole M, et al. 2015 Heart Rhythm Society Expert Consensus Statement on the Diagnosis and Treatment of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia, and Vasovagal Syncope. Heart Rhythm 2015; 12: e41–e63. DOI: https://doi.org/10.1016/j.hrthm.2015.03.029

Vernino S, Bourne KM, Stiles LE, Grubb BP, Fedorowski A, Stewart JM, et al. Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting – Part 1. Auton Neurosci 2021; 235: 102828. DOI: https://doi.org/10.1016/j.autneu.2021.102828

Isaac R, Corrado J, Sivan M. Detecting orthostatic intolerance in long COVID in a clinic setting. Int J Environ Res Public Health 2023; 20: 5804. DOI: https://doi.org/10.3390/ijerph20105804

Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis 2022; 22: e102–e107. DOI: https://doi.org/10.1016/S1473-3099(21)00703-9

Robertson D. The epidemic of orthostatic tachycardia and orthostatic intolerance. Am J Med Sci 1999; 317: 75–77. DOI: https://doi.org/10.1016/S0002-9629(15)40480-X

Mallick D, Goyal L, Chourasia P, Zapata MR, Yashi K, Surani S. COVID-19 induced postural orthostatic tachycardia syndrome (POTS): a review. Cureus 2023; 15: e36955. DOI: https://doi.org/10.7759/cureus.36955

Lee J, Vernon SD, Jeys P, Ali W, Campos A, Unutmaz D, et al.L Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients. J Transl Med 2020; 18: 314. DOI: https://doi.org/10.1186/s12967-020-02481-y

Anderson JW, Lambert EA, Sari CI, Dawood T, Esler MD, Vaddadi G, et al. Cognitive function, health-related quality of life, and symptoms of depression and anxiety sensitivity are impaired in patients with the postural orthostatic tachycardia syndrome (POTS). Front Physiol 2014; 5: 230. DOI: https://doi.org/10.3389/fphys.2014.00230

Knoop I, Picariello F, Jenkinson E, Gall N, Chisari C, Moss-Morris R. Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): a narrative review of observational and interventional studies. Auton Neurosci 2023; 244: 103052. DOI: https://doi.org/10.1016/j.autneu.2022.103052

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Mar PL, Raj SR. Postural orthostatic tachycardia syndrome: mechanisms and new therapies. Annu Rev Med 2020; 71: 235–248. DOI: https://doi.org/10.1146/annurev-med-041818-011630

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Published

2026-07-02

How to Cite

Siebler, M., Maier, A., Theiss, S., Bergé, S., Bittner, A., Schiefelbein, G., … Raab, D. (2026). NASA lean test detects postural orthostatic tachycardia in chronic post-COVID. Journal of Rehabilitation Medicine, 58, jrm45865. https://doi.org/10.2340/jrm.v58.45865

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