Long-term medical and psychosocial vulnerability after home return following severe traumatic brain injury

Authors

  • Andrea Calderone IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy
  • Carmela Rifici IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy
  • Donatella Bonaiuti Golgi Redaelli Institute, Milan, Italy
  • Alfredo Manuli Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy
  • Daniele Bruschetta Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy
  • Marco Piccione IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy
  • Tina Balletta IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy
  • Angelo Quartarone IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy
  • Rocco Salvatore Calabrò IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy

DOI:

https://doi.org/10.2340/jrm.v58.46093

Keywords:

brain injuries, traumatic, rehabilitation, longitudinal studies, community participation, quality of life, patient-reported outcome measures, latent class analysis

Abstract

Objective: To identify a 5-year medical and psychosocial vulnerability profile among adults living at home 1 year after severe TBI and examine associated early characteristics.

Design: Retrospective secondary analysis of a multicentre longitudinal cohort.

Subjects/Patients: Adults aged 16 years or older with operationally defined severe traumatic brain injury, private residence at 1 year, linked 5-year follow-up, and complete data for 4 profile indicators.

Methods: Latent class analysis used 5-year rehospitalization, PHQ-9, GAD-7, and Satisfaction With Life Scale scores dichotomized with prespecified clinically interpretable thresholds. External rehabilitation outcomes and early associated factors were examined descriptively and with multivariable logistic regression.

Results: Among 2,835 participants, a 2-class solution identified a lower-vulnerability profile (n = 2,361) and a multidomain vulnerability profile (n = 474). The latter showed more depressive symptoms, anxiety symptoms, low life satisfaction, and rehospitalization, with poorer 5-year functioning, participation, health, productive status, and higher frequency of non-private residence. Better 1-year global outcome was protective; female sex, preinjury illicit drug use, and living alone at 1 year were associated with assignment to this profile.

Conclusion: Home return after severe traumatic brain injury should be treated as a transition point for longitudinal rehabilitation surveillance.

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References

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Published

2026-07-23

How to Cite

Calderone, A., Rifici, C., Bonaiuti, D., Manuli, A., Bruschetta, D., Piccione, M., … Calabrò, R. S. (2026). Long-term medical and psychosocial vulnerability after home return following severe traumatic brain injury. Journal of Rehabilitation Medicine, 58, jrm46093. https://doi.org/10.2340/jrm.v58.46093

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