Lipoedema in an adolescent male following valproate discontinuation: a case report
DOI:
https://doi.org/10.2340/jrm.v58.46824Keywords:
lipedema, valproic acid, desmopressin, Complex Decongestive Therapy, ICF, rehabilitationDownloads
References
Faerber G, Cornely M, Daubert C, Erbacher G, Fink J, Hirsch T, et al. S2k guideline for lipedema. J Dtsch Dermatol Ges 2024; 22: 1303–1315.
Amato ACM, Saucedo DZ, Santos KDS, Benitti DA. Ultrasound criteria for lipedema diagnosis. Phlebology 2021; 36: 651–658.
Kruppa P, Crescenzi R, Faerber G, Forner-Cordero I, Cornely M, Shayan R et al. Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam. Nature Communications 2026; 17: 427.
Bertlich M, Jakob M, Bertlich I, Schift R, Bertlich R. Lipedema in a male patient: report of a rare case – management and review of the literature. GMS Interdiscip Plast Reconstr Surg DGPW 2021; 10: Doc11.
Benz T, Lehmann S, Sandor PS, Angst F. Relationship between subjectively rated and objectively tested physical function across six different medical diagnoses. J Rehabil Med 2023; 55: jrm9383.
Kruppa P, Georgiou I, Biermann N, Prantl L, Klein-Weigel P, Ghods M. Lipedema: pathogenesis, diagnosis, and treatment options. Dtsch Arztebl Int 2020; 117: 396–403.
Lacerda LS, Alves UD, Zanier JF, Machado DC, Camilo GB, Lopes AJ. Differential diagnoses of overgrowth syndromes. Radiol Res Pract 2014; 2014: 947451.
Langendoen SI, Habbema L, Nijsten TEC, Neumann HAM. Lipoedema: from clinical presentation to therapy. Br J Dermatol 2009; 161: 980–986.
Lagace DC, Nachtigal MW. Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis. J Biol Chem 2004; 279: 18851–18860.
Grünig D, Szabo L, Marbet M, Krähenbühl S. Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells. Biochem Pharmacol 2020; 177: 113860.
Verrotti A, D’Egidio C, Mohn A, Coppola G, Chiarelli F. Weight gain following valproic acid therapy. Obes Rev 2011; 12: e32–43.
Anekwe CV, Ahn YJ, Bajaj SS, Stanford FC. Pharmacotherapy causing weight gain and metabolic alteration in those with obesity and obesity-related conditions. Ann N Y Acad Sci 2024; 1533: 145–155.
Zhao S, Wang X, Wang Y, Xu J, Zhu G, Zhao C, et al. Effects of valproate on reproductive endocrine function in male patients with epilepsy. Epilepsy Behav 2018; 85: 120–128.
Kaufmann JE, Oksche A, Wollheim CB, Günther G, Rosenthal W, Vischer UM. Vasopressin-induced von Willebrand factor secretion involves V2 receptors and cAMP. J Clin Invest 2000; 106: 107–116.
Child AH, Gordon KD, Sharpe P, Brice G, Ostergaard P, Jeffery S, et al. Lipedema: an inherited condition. Am J Med Genet A 2010; 152A: 970–976.
Herbst KL, Kahn LA, Iker E, Ehrlich C, Wright T, McHutchison L, et al. Standard of care for lipedema in the United States. Phlebology 2021; 36: 779–796.
Downloads
Published
How to Cite
License
Copyright (c) 2026 Serkan Kemer, Aysel Özge Kemer, Elif Can Özdemir, Ayşegül Yaman
This work is licensed under a Creative Commons Attribution 4.0 International License.
All digitalized JRM contents is available freely online. The Foundation for Rehabilitation Medicine owns the copyright for all material published until volume 40 (2008), as from volume 41 (2009) authors retain copyright to their work and as from volume 49 (2017) the journal has been published Open Access, under CC-BY-NC licences (unless otherwise specified). The CC-BY-NC licenses allow third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
From 2024, articles are published under the CC-BY licence. This license permits sharing, adapting, and using the material for any purpose, including commercial use, with the condition of providing full attribution to the original publication.
