Human herpes virus 6 encephalitis in allopurinol-induced hypersensitivity syndrome
DOI:
https://doi.org/10.1080/00015550310007481Abstract
To investigate the pathophysiological role of fibroblasts in tissue metabolism, we analysed gelatin-degrading enzymes secreted from skin cells in culture. Using a gelatin-zymography method, matrix metalloproteinase (MMP)-2 was constitutively secreted from fibroblasts, whereas both MMP-2 and MMP-9 were secreted from keratinocytes. MMP-9 expression by fibroblasts was induced by the addition of transforming growth factor (TGF)-beta1 or tumour necrosis factor (TNF)-alpha to the cultures. Moreover, TGF-beta1, TNF-alpha, or epidermal growth factor augmented the secretion of MMP-2 from fibroblasts. These results indicate that MMP-9 together with MMP-2 secreted from fibroblasts could play important roles in tissue metabolism, including cytokine-induced inflammation.Downloads
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Published
2003-05-09
How to Cite
Masaki, T., Fukunaga, A., Tohyama, M., Koda, Y., Okuda, S., Maeda, N., … Ueda, M. (2003). Human herpes virus 6 encephalitis in allopurinol-induced hypersensitivity syndrome. Acta Dermato-Venereologica, 83(2), 128–131. https://doi.org/10.1080/00015550310007481
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