Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts
DOI:
https://doi.org/10.1080/00015550260132442Abstract
In this study we investigated the capability of Treponema pallidum to stimulate human dermal fibroblasts to produce interstitial collagenase (MMP-1), which is needed to degrade type I collagen, the most abundant component of the human dermis. When T. pallidum was added to human dermal fibroblast culture, both the amount of secreted MMP-1 and its mRNA levels were increased. Our results show that T. pallidum can stimulate host human fibroblasts to increase the synthesis of MMP-1, which may act as a virulence factor of the organism.Downloads
Download data is not yet available.
Downloads
Published
2002-10-02
How to Cite
Chung, K. Y., Kim, K.-S., Lee, M. G., Chang, N. S., & Lee, J. B. (2002). Treponema pallidum induces up-regulation of interstitial collagenase in human dermal fibroblasts. Acta Dermato-Venereologica, 82(3), 174–178. https://doi.org/10.1080/00015550260132442
Issue
Section
Articles
License
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
