A case of exaggerated mosquito-bite hypersensitivity with Epstein-Barr virus-positive inflammatory cells in the bite lesion

Authors

  • Tokuya Ohsawa
  • Tsukasa Morimura
  • Yoshitaka Hagari
  • Tetsuji Kawakami
  • Motoyuki Mihara
  • Kazumitsu Hirai
  • Kazufumi Ikuta
  • Masanao Murakami
  • Takeshi Sairenji
  • Tomocho Matsuse

DOI:

https://doi.org/10.1080/000155501317140106

Abstract

We describe a unique patient with mosquito-bite hypersensitivity who had extremely high titres of Epstein-Barr virus antibodies. For many years he developed intractable ulcers on the sites of mosquito-bite. Epstein-Barr virus infection was detected in almost all inflammatory cells in the ulcers and in the peripheral blood lymphocytes by using in situ hybridization to Epstein-Barr virus-encoded small ribonucleic acids and by polymerase chain reaction to Epstein-Barr virus DNA. The inflammatory cells in the ulcers were positive for T-cell marker. Our results suggest that the Epstein-Barr virus infection in T cells may participate in the pathogenesis of exaggerated mosquito hypersensitivity and in delayed healing of ulcers on the sites of mosquito-bite.

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Published

2001-09-20

How to Cite

Ohsawa, T., Morimura, T., Hagari, Y., Kawakami, T., Mihara, M., Hirai, K., … Matsuse, T. (2001). A case of exaggerated mosquito-bite hypersensitivity with Epstein-Barr virus-positive inflammatory cells in the bite lesion. Acta Dermato-Venereologica, 81(5), 360–363. https://doi.org/10.1080/000155501317140106

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Section

Articles