Thomsen-Friedenreich and Its Precursor (Tn) Antigen Expression in Normal Skin and in Benign Cutaneous Tumours: a Marker for Sebaceous Differentiation.
DOI:
https://doi.org/10.1080/000155598441468Abstract
The Thomsen-Friedenreich (T) antigen is the core disaccharide of cancer-associated carbohydrates;whose expression allegedly correlates with the prognosis of some carcinomas. We studied the expression of the T antigen and its precursor (Tn) with monoclonal antibodies in formalin-fixed specimens of normal skin and various benign cutaneous tumours and inflammatory lesions (n: 105). In normal skin;both antigens were consistently expressed within the cytoplasm of mature sebocytes and rarely over the luminal surface of secretory sweat gland cells. All (21/21) sebaceous tumours showed strong T/Tn positivityDownloads
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