Ultrastructure of murine dermis following topical application of the vitamin D3 analogue KH-1060.
DOI:
https://doi.org/10.2340/0001555577198202Abstract
The aim of this study, was to observe the effects of KH-1060, a new vitamin D3 analogue, on the dermis of hairless mice by electron microscopy. KH-1060 (0.2 micrograms/ml in isopropanol) or KH-1060 following betamethasone 17-valerate (2 mg/ml in isopropanol) was applied topically to the backs of hairless mice for 4 weeks. KH-1060 increased the number of dermal fibroblasts, the cytoplasm of which was dominated by secretory components. Mast cells contained normal mature granules and degranulated after disintegration. No extrusion of non-disintegrated granules was seen. Collagen fibrils were thickened and increased in numberDownloads
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Published
1997-05-01
How to Cite
Kobayasi, T. (1997). Ultrastructure of murine dermis following topical application of the vitamin D3 analogue KH-1060. Acta Dermato-Venereologica, 77(3), 198–202. https://doi.org/10.2340/0001555577198202
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